Disulfide-Based Poly(amido amine)s for siRNA Delivery: Effects of Structure on siRNA Complexation, Cellular Uptake, Gene Silencing and Toxicity

PURPOSE: RNA interference (RNAi) is a process by which small interfering RNAs (siRNA) induce sequence-specific gene silencing. Therefore, siRNA is an emerging promise as a novel therapeutic. In order to realize the high expectations for therapeutic applications, efficient delivery systems for siRNA...

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Detalles Bibliográficos
Autores principales: Vader, Pieter, van der Aa, Leonardus J., Engbersen, Johan F. J., Storm, Gert, Schiffelers, Raymond M.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073045/
https://www.ncbi.nlm.nih.gov/pubmed/21181546
http://dx.doi.org/10.1007/s11095-010-0344-y

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