The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus

OBJECTIVES: The antistaphylococcal pyrrolobenzodiazepine dimer ELB-21 forms multiple adducts with duplex DNA through covalent interactions with appropriately spaced guanine residues; it is now known to form interstrand and intrastrand adducts with oligonucleotide sequences of variable length. We det...

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Detalles Bibliográficos
Autores principales: Rosado, Helena, Rahman, Khondaker M., Feuerbaum, Eva-Anne, Hinds, Jason, Thurston, David E., Taylor, Peter W.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073633/
https://www.ncbi.nlm.nih.gov/pubmed/21393142
http://dx.doi.org/10.1093/jac/dkr044

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