Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells

Cyclin E supports pre-replication complex (pre-RC) assembly, while cyclin A-associated kinase activates DNA synthesis. We show that cyclin E, but not A, is mounted upon the nuclear matrix in sub-nuclear foci in differentiated vertebrate cells, but not in undifferentiated cells or cancer cells. In mu...

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Detalles Bibliográficos
Autores principales: Munkley, Jennifer, Copeland, Nikki A., Moignard, Victoria, Knight, John R. P., Greaves, Erin, Ramsbottom, Simon A., Pownall, Mary E., Southgate, Jennifer, Ainscough, Justin F.-X., Coverley, Dawn
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074132/
https://www.ncbi.nlm.nih.gov/pubmed/21109536
http://dx.doi.org/10.1093/nar/gkq1190

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