Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway

Mismatch uracil DNA glycosylase (Mug) from Escherichia coli is an initiating enzyme in the base-excision repair pathway. As with other DNA glycosylases, the abasic product is potentially more harmful than the initial lesion. Since Mug is known to bind its product tightly, inhibiting enzyme turnover,...

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Detalles Bibliográficos
Autores principales: Grippon, Seden, Zhao, Qiyuan, Robinson, Tom, Marshall, Jacqueline J. T., O’Neill, Rory J., Manning, Hugh, Kennedy, Gordon, Dunsby, Christopher, Neil, Mark, Halford, Stephen E., French, Paul M. W., Baldwin, Geoff S.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074160/
https://www.ncbi.nlm.nih.gov/pubmed/21112870
http://dx.doi.org/10.1093/nar/gkq913

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