SETD6 lysine methylation of RelA couples GLP activity at chromatin to tonic repression of NF-κB signaling

Protein lysine methylation signaling is implicated in diverse biological and disease processes. Yet the catalytic activity and substrate specificity are unknown for many human protein lysine methyltransferases (PKMTs). We screened over forty candidate PKMTs and identified SETD6 as a methyltransferas...

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Detalles Bibliográficos
Autores principales: Levy, Dan, Kuo, Alex J., Chang, Yanqi, Schaefer, Uwe, Kitson, Christopher, Cheung, Peggie, Espejo, Alexsandra, Zee, Barry M., Liu, Chih Long, Tangsombatvisit, Stephanie, Tennen, Ruth I., Kuo, Andrew Y., Tanjing, Song, Cheung, Regina, Chua, Katrin F., Utz, Paul J., Shi, Xiaobing, Prinjha, Rab K., Lee, Kevin, Garcia, Benjamin A., Bedford, Mark T., Tarakhovsky, Alexander, Cheng, Xiaodong, Gozani, Or
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074206/
https://www.ncbi.nlm.nih.gov/pubmed/21131967
http://dx.doi.org/10.1038/ni.1968

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