Effects of the Oil and Mucilage from Flaxseed (Linum Usitatissimum) on Gastric Lesions Induced by Ethanol in Rats

The anti-ulcer activity of the oil and mucilage obtained from flaxseed (Linum usitatissimum) was evaluated in a rat model of ethanol-induced gastric ulcer. Our results show that pretreatment of rats with flaxseed oil and flaxseed mucilage significantly reduced the number and length of gastric ulcers...

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Detalles Bibliográficos
Autores principales: Dugani, A, Auzzi, A, Naas, F, Megwez, S
Formato: Texto
Lenguaje:English
Publicado: CoAction Publishing 2008
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074307/
https://www.ncbi.nlm.nih.gov/pubmed/21503150
http://dx.doi.org/10.4176/080612
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author Dugani, A
Auzzi, A
Naas, F
Megwez, S
author_facet Dugani, A
Auzzi, A
Naas, F
Megwez, S
author_sort Dugani, A
collection PubMed
description The anti-ulcer activity of the oil and mucilage obtained from flaxseed (Linum usitatissimum) was evaluated in a rat model of ethanol-induced gastric ulcer. Our results show that pretreatment of rats with flaxseed oil and flaxseed mucilage significantly reduced the number and length of gastric ulcers induced by ethanol. Flaxseed oil was more effective than flaxseed mucilage in reducing the number of ulcers. The reduction in ulcer severity (cumulative length in mm) provided by an oral dose of flaxseed oil (5 ml/kg) was more prominent than that obtained by ranitidine (50 mg/kg). This study indicates that both flaxseed oil and flaxseed mucilage can provide a cytoprotective effect against ethanol-induced gastric ulcers in rats.
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spelling pubmed-30743072011-04-18 Effects of the Oil and Mucilage from Flaxseed (Linum Usitatissimum) on Gastric Lesions Induced by Ethanol in Rats Dugani, A Auzzi, A Naas, F Megwez, S Libyan J Med Original Article The anti-ulcer activity of the oil and mucilage obtained from flaxseed (Linum usitatissimum) was evaluated in a rat model of ethanol-induced gastric ulcer. Our results show that pretreatment of rats with flaxseed oil and flaxseed mucilage significantly reduced the number and length of gastric ulcers induced by ethanol. Flaxseed oil was more effective than flaxseed mucilage in reducing the number of ulcers. The reduction in ulcer severity (cumulative length in mm) provided by an oral dose of flaxseed oil (5 ml/kg) was more prominent than that obtained by ranitidine (50 mg/kg). This study indicates that both flaxseed oil and flaxseed mucilage can provide a cytoprotective effect against ethanol-induced gastric ulcers in rats. CoAction Publishing 2008-12-01 /pmc/articles/PMC3074307/ /pubmed/21503150 http://dx.doi.org/10.4176/080612 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dugani, A
Auzzi, A
Naas, F
Megwez, S
Effects of the Oil and Mucilage from Flaxseed (Linum Usitatissimum) on Gastric Lesions Induced by Ethanol in Rats
title Effects of the Oil and Mucilage from Flaxseed (Linum Usitatissimum) on Gastric Lesions Induced by Ethanol in Rats
title_full Effects of the Oil and Mucilage from Flaxseed (Linum Usitatissimum) on Gastric Lesions Induced by Ethanol in Rats
title_fullStr Effects of the Oil and Mucilage from Flaxseed (Linum Usitatissimum) on Gastric Lesions Induced by Ethanol in Rats
title_full_unstemmed Effects of the Oil and Mucilage from Flaxseed (Linum Usitatissimum) on Gastric Lesions Induced by Ethanol in Rats
title_short Effects of the Oil and Mucilage from Flaxseed (Linum Usitatissimum) on Gastric Lesions Induced by Ethanol in Rats
title_sort effects of the oil and mucilage from flaxseed (linum usitatissimum) on gastric lesions induced by ethanol in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074307/
https://www.ncbi.nlm.nih.gov/pubmed/21503150
http://dx.doi.org/10.4176/080612
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AT naasf effectsoftheoilandmucilagefromflaxseedlinumusitatissimumongastriclesionsinducedbyethanolinrats
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