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Topographical Organization of the Pedunculopontine Nucleus

Neurons in the pedunculopontine nucleus (PPN) exhibit a wide heterogeneity in terms of their neurochemical nature, their discharge properties, and their connectivity. Such characteristics are reflected in their functional properties and the behaviors in which they are involved, ranging from motor to...

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Detalles Bibliográficos
Autores principales: Martinez-Gonzalez, Cristina, Bolam, J. Paul, Mena-Segovia, Juan
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074429/
https://www.ncbi.nlm.nih.gov/pubmed/21503154
http://dx.doi.org/10.3389/fnana.2011.00022
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author Martinez-Gonzalez, Cristina
Bolam, J. Paul
Mena-Segovia, Juan
author_facet Martinez-Gonzalez, Cristina
Bolam, J. Paul
Mena-Segovia, Juan
author_sort Martinez-Gonzalez, Cristina
collection PubMed
description Neurons in the pedunculopontine nucleus (PPN) exhibit a wide heterogeneity in terms of their neurochemical nature, their discharge properties, and their connectivity. Such characteristics are reflected in their functional properties and the behaviors in which they are involved, ranging from motor to cognitive functions, and the regulation of brain states. A clue to understand this functional versatility arises from the internal organization of the PPN. Thus, two main areas of the PPN have been described, the rostral and the caudal, which display remarkable differences in terms of the distribution of neurons with similar phenotype and the projections that originate from them. Here we review these differences with the premise that in order to understand the function of the PPN it is necessary to understand its intricate connectivity. We support the case that the PPN should not be considered as a homogeneous structure and conclude that the differences between rostral and caudal PPN, along with their intrinsic connectivity, may underlie the basis of its complexity.
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spelling pubmed-30744292011-04-18 Topographical Organization of the Pedunculopontine Nucleus Martinez-Gonzalez, Cristina Bolam, J. Paul Mena-Segovia, Juan Front Neuroanat Neuroscience Neurons in the pedunculopontine nucleus (PPN) exhibit a wide heterogeneity in terms of their neurochemical nature, their discharge properties, and their connectivity. Such characteristics are reflected in their functional properties and the behaviors in which they are involved, ranging from motor to cognitive functions, and the regulation of brain states. A clue to understand this functional versatility arises from the internal organization of the PPN. Thus, two main areas of the PPN have been described, the rostral and the caudal, which display remarkable differences in terms of the distribution of neurons with similar phenotype and the projections that originate from them. Here we review these differences with the premise that in order to understand the function of the PPN it is necessary to understand its intricate connectivity. We support the case that the PPN should not be considered as a homogeneous structure and conclude that the differences between rostral and caudal PPN, along with their intrinsic connectivity, may underlie the basis of its complexity. Frontiers Research Foundation 2011-04-05 /pmc/articles/PMC3074429/ /pubmed/21503154 http://dx.doi.org/10.3389/fnana.2011.00022 Text en Copyright © 2011 Martinez-Gonzalez, Bolam and Mena-Segovia. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Neuroscience
Martinez-Gonzalez, Cristina
Bolam, J. Paul
Mena-Segovia, Juan
Topographical Organization of the Pedunculopontine Nucleus
title Topographical Organization of the Pedunculopontine Nucleus
title_full Topographical Organization of the Pedunculopontine Nucleus
title_fullStr Topographical Organization of the Pedunculopontine Nucleus
title_full_unstemmed Topographical Organization of the Pedunculopontine Nucleus
title_short Topographical Organization of the Pedunculopontine Nucleus
title_sort topographical organization of the pedunculopontine nucleus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074429/
https://www.ncbi.nlm.nih.gov/pubmed/21503154
http://dx.doi.org/10.3389/fnana.2011.00022
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