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Systemic lupus erythematosus associated with type 4 renal tubular acidosis: a case report and review of the literature

INTRODUCTION: Type 4 renal tubular acidosis is an uncommon clinical manifestation of systemic lupus erythematosus and has been reported to portend a poor prognosis. To the best of our knowledge, this is the first case report which highlights the successful management of a patient with systemic lupus...

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Autores principales: Porteous, Haldane, Morgan, Nadia, Lanfranco, Julio, Garcia-Buitrago, Monica, Young, Larry, Lenz, Oliver
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074556/
https://www.ncbi.nlm.nih.gov/pubmed/21435204
http://dx.doi.org/10.1186/1752-1947-5-114
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author Porteous, Haldane
Morgan, Nadia
Lanfranco, Julio
Garcia-Buitrago, Monica
Young, Larry
Lenz, Oliver
author_facet Porteous, Haldane
Morgan, Nadia
Lanfranco, Julio
Garcia-Buitrago, Monica
Young, Larry
Lenz, Oliver
author_sort Porteous, Haldane
collection PubMed
description INTRODUCTION: Type 4 renal tubular acidosis is an uncommon clinical manifestation of systemic lupus erythematosus and has been reported to portend a poor prognosis. To the best of our knowledge, this is the first case report which highlights the successful management of a patient with systemic lupus erythematosus complicated by type 4 renal tubular acidosis who did not do poorly. CASE PRESENTATION: A 44-year-old Hispanic woman developed a non-anion gap hyperkalemic metabolic acidosis consistent with type 4 renal tubular acidosis while being treated in the hospital for recently diagnosed systemic lupus erythematosus with multi-organ involvement. She responded well to treatment with corticosteroids, hydroxychloroquine and mycophenolate mofetil. Normal renal function was achieved prior to discharge and remained normal at the patient's one-month follow-up examination. CONCLUSION: This case increases awareness of an uncommon association between systemic lupus erythematosus and type 4 renal tubular acidosis and suggests a positive impact of early diagnosis and appropriate immunosuppressive treatment on the patient's outcome.
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spelling pubmed-30745562011-04-13 Systemic lupus erythematosus associated with type 4 renal tubular acidosis: a case report and review of the literature Porteous, Haldane Morgan, Nadia Lanfranco, Julio Garcia-Buitrago, Monica Young, Larry Lenz, Oliver J Med Case Reports Case Report INTRODUCTION: Type 4 renal tubular acidosis is an uncommon clinical manifestation of systemic lupus erythematosus and has been reported to portend a poor prognosis. To the best of our knowledge, this is the first case report which highlights the successful management of a patient with systemic lupus erythematosus complicated by type 4 renal tubular acidosis who did not do poorly. CASE PRESENTATION: A 44-year-old Hispanic woman developed a non-anion gap hyperkalemic metabolic acidosis consistent with type 4 renal tubular acidosis while being treated in the hospital for recently diagnosed systemic lupus erythematosus with multi-organ involvement. She responded well to treatment with corticosteroids, hydroxychloroquine and mycophenolate mofetil. Normal renal function was achieved prior to discharge and remained normal at the patient's one-month follow-up examination. CONCLUSION: This case increases awareness of an uncommon association between systemic lupus erythematosus and type 4 renal tubular acidosis and suggests a positive impact of early diagnosis and appropriate immunosuppressive treatment on the patient's outcome. BioMed Central 2011-03-24 /pmc/articles/PMC3074556/ /pubmed/21435204 http://dx.doi.org/10.1186/1752-1947-5-114 Text en Copyright ©2011 Porteous et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Porteous, Haldane
Morgan, Nadia
Lanfranco, Julio
Garcia-Buitrago, Monica
Young, Larry
Lenz, Oliver
Systemic lupus erythematosus associated with type 4 renal tubular acidosis: a case report and review of the literature
title Systemic lupus erythematosus associated with type 4 renal tubular acidosis: a case report and review of the literature
title_full Systemic lupus erythematosus associated with type 4 renal tubular acidosis: a case report and review of the literature
title_fullStr Systemic lupus erythematosus associated with type 4 renal tubular acidosis: a case report and review of the literature
title_full_unstemmed Systemic lupus erythematosus associated with type 4 renal tubular acidosis: a case report and review of the literature
title_short Systemic lupus erythematosus associated with type 4 renal tubular acidosis: a case report and review of the literature
title_sort systemic lupus erythematosus associated with type 4 renal tubular acidosis: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074556/
https://www.ncbi.nlm.nih.gov/pubmed/21435204
http://dx.doi.org/10.1186/1752-1947-5-114
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