A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome

We report the case of a 46-year-old female patient with WDHA (watery diarrhea/hypokalemia/achlorhydria) syndrome caused by a pancreatic polypeptide-producing tumor in the head of the pancreas. Whereas VIP and other pancreatic endocrine hormones were in the normal range, only serum levels of pancreat...

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Autores principales: Amrilleva, Vera, Slater, Emily P., Waldmann, Jens, Bonorden, Dorothee, Fendrich, Volker
Formato: Texto
Lenguaje:English
Publicado: S. Karger AG 2008
Materias:
Published: July 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075149/
https://www.ncbi.nlm.nih.gov/pubmed/21490894
http://dx.doi.org/10.1159/000142739
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author Amrilleva, Vera
Slater, Emily P.
Waldmann, Jens
Bonorden, Dorothee
Fendrich, Volker
author_facet Amrilleva, Vera
Slater, Emily P.
Waldmann, Jens
Bonorden, Dorothee
Fendrich, Volker
author_sort Amrilleva, Vera
collection PubMed
description We report the case of a 46-year-old female patient with WDHA (watery diarrhea/hypokalemia/achlorhydria) syndrome caused by a pancreatic polypeptide-producing tumor in the head of the pancreas. Whereas VIP and other pancreatic endocrine hormones were in the normal range, only serum levels of pancreatic polypeptide were elevated. Imaging studies identified a pancreatic tumor in the head of the gland. After laparotomy, the tumor of 3 cm in size was enucleated. Final pathology documented a pancreatic endocrine tumor with immunohistochemical staining demonstrating the presence of pancreatic polypeptide. The patient remained cured after a follow-up of more than three years. The present case illustrates that, although rare, WDHA syndrome may be associated with a pancreatic polypeptide-secreting endocrine tumor of the pancreas.
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spelling pubmed-30751492011-04-13 A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome Amrilleva, Vera Slater, Emily P. Waldmann, Jens Bonorden, Dorothee Fendrich, Volker Case Rep Gastroenterol Published: July 2008 We report the case of a 46-year-old female patient with WDHA (watery diarrhea/hypokalemia/achlorhydria) syndrome caused by a pancreatic polypeptide-producing tumor in the head of the pancreas. Whereas VIP and other pancreatic endocrine hormones were in the normal range, only serum levels of pancreatic polypeptide were elevated. Imaging studies identified a pancreatic tumor in the head of the gland. After laparotomy, the tumor of 3 cm in size was enucleated. Final pathology documented a pancreatic endocrine tumor with immunohistochemical staining demonstrating the presence of pancreatic polypeptide. The patient remained cured after a follow-up of more than three years. The present case illustrates that, although rare, WDHA syndrome may be associated with a pancreatic polypeptide-secreting endocrine tumor of the pancreas. S. Karger AG 2008-07-09 /pmc/articles/PMC3075149/ /pubmed/21490894 http://dx.doi.org/10.1159/000142739 Text en Copyright © 2008 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: July 2008
Amrilleva, Vera
Slater, Emily P.
Waldmann, Jens
Bonorden, Dorothee
Fendrich, Volker
A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome
title A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome
title_full A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome
title_fullStr A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome
title_full_unstemmed A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome
title_short A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome
title_sort pancreatic polypeptide-producing pancreatic tumor causing wdha syndrome
topic Published: July 2008
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075149/
https://www.ncbi.nlm.nih.gov/pubmed/21490894
http://dx.doi.org/10.1159/000142739
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