Prohepcidin Levels in Refractory Anaemia Caused by Lead Poisoning

Recent research evidence suggests a central role for hepcidin in iron homeostasis. Hepcidin is a hormone synthesized in the liver. Hepcidin is also thought to play a vital role in the pathogenic mechanism of anaemia in patients with inflammation or chronic disease. A 38-year-old female who presented...

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Autores principales: Arnold, Jayantha, Busbridge, Mark, Sangwaiya, Arvind, Bhatkal, Bharati, Paskaran, Parth, Pal, Arabinda, Geoghegan, Frank, Kealey, Terence
Formato: Texto
Lenguaje:English
Publicado: S. Karger AG 2008
Materias:
Published: January 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075166/
https://www.ncbi.nlm.nih.gov/pubmed/21490838
http://dx.doi.org/10.1159/000118035
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author Arnold, Jayantha
Busbridge, Mark
Sangwaiya, Arvind
Bhatkal, Bharati
Paskaran, Parth
Pal, Arabinda
Geoghegan, Frank
Kealey, Terence
author_facet Arnold, Jayantha
Busbridge, Mark
Sangwaiya, Arvind
Bhatkal, Bharati
Paskaran, Parth
Pal, Arabinda
Geoghegan, Frank
Kealey, Terence
author_sort Arnold, Jayantha
collection PubMed
description Recent research evidence suggests a central role for hepcidin in iron homeostasis. Hepcidin is a hormone synthesized in the liver. Hepcidin is also thought to play a vital role in the pathogenic mechanism of anaemia in patients with inflammation or chronic disease. A 38-year-old female who presented with recurrent abdominal pain was found to have raised urinary porphyrins and a blood lead level of 779 μg/l. Her haemoglobin level was 8.3 g/dl. Her MCV was normal. Serum ferritin, B12 and folate were normal. Her serum prohepcidin level was 2,489 ng/ml (normal <450 ng/ml). To our knowledge, this is the first report of raised prohepcidin levels in a patient with anaemia of chronic disease resulting from lead poisoning.
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spelling pubmed-30751662011-04-13 Prohepcidin Levels in Refractory Anaemia Caused by Lead Poisoning Arnold, Jayantha Busbridge, Mark Sangwaiya, Arvind Bhatkal, Bharati Paskaran, Parth Pal, Arabinda Geoghegan, Frank Kealey, Terence Case Rep Gastroenterol Published: January 2008 Recent research evidence suggests a central role for hepcidin in iron homeostasis. Hepcidin is a hormone synthesized in the liver. Hepcidin is also thought to play a vital role in the pathogenic mechanism of anaemia in patients with inflammation or chronic disease. A 38-year-old female who presented with recurrent abdominal pain was found to have raised urinary porphyrins and a blood lead level of 779 μg/l. Her haemoglobin level was 8.3 g/dl. Her MCV was normal. Serum ferritin, B12 and folate were normal. Her serum prohepcidin level was 2,489 ng/ml (normal <450 ng/ml). To our knowledge, this is the first report of raised prohepcidin levels in a patient with anaemia of chronic disease resulting from lead poisoning. S. Karger AG 2008-02-28 /pmc/articles/PMC3075166/ /pubmed/21490838 http://dx.doi.org/10.1159/000118035 Text en Copyright © 2008 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: January 2008
Arnold, Jayantha
Busbridge, Mark
Sangwaiya, Arvind
Bhatkal, Bharati
Paskaran, Parth
Pal, Arabinda
Geoghegan, Frank
Kealey, Terence
Prohepcidin Levels in Refractory Anaemia Caused by Lead Poisoning
title Prohepcidin Levels in Refractory Anaemia Caused by Lead Poisoning
title_full Prohepcidin Levels in Refractory Anaemia Caused by Lead Poisoning
title_fullStr Prohepcidin Levels in Refractory Anaemia Caused by Lead Poisoning
title_full_unstemmed Prohepcidin Levels in Refractory Anaemia Caused by Lead Poisoning
title_short Prohepcidin Levels in Refractory Anaemia Caused by Lead Poisoning
title_sort prohepcidin levels in refractory anaemia caused by lead poisoning
topic Published: January 2008
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075166/
https://www.ncbi.nlm.nih.gov/pubmed/21490838
http://dx.doi.org/10.1159/000118035
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