Fatal Bile Duct Necrosis: A Rare Complication of Transcatheter Arterial Chemoembolization in a Patient with Endocrine Hepatic Metastasis

We report the first case of fatal bile duct necrosis following transcatheter arterial chemoembolization (TACE) in a 58-year-old woman. The patient underwent two TACEs to treat hepatic metastases from an ileal endocrine tumor. Persistent cholestasis occurred after the second procedure, leading to the...

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Detalles Bibliográficos
Autores principales: Pelletier, Anne-Laure, Hammel, Pascal, Zappa, Magali, Bedossa, Pierre, Rebours, Vinciane, Hentic, Olivia, Maire, Frédérique, Levy, Philippe, Ruszniewski, Philippe
Formato: Texto
Lenguaje:English
Publicado: S. Karger AG 2008
Materias:
Published: November 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075197/
https://www.ncbi.nlm.nih.gov/pubmed/21490869
http://dx.doi.org/10.1159/000158542
Descripción
Sumario:We report the first case of fatal bile duct necrosis following transcatheter arterial chemoembolization (TACE) in a 58-year-old woman. The patient underwent two TACEs to treat hepatic metastases from an ileal endocrine tumor. Persistent cholestasis occurred after the second procedure, leading to the diagnosis of bile duct necrosis confirmed by liver biopsy. The patient died of liver failure with encephalopathy six months after the second TACE. Even though this complication is very rare, physicians should consider this diagnosis in patients who develop chronic, marked cholestasis following a TACE procedure.

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