Cargando…

Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation

Autophagy has recently been implicated in both the prevention and progression of cancer. However, the molecular basis for the relationship between autophagy induction and the initial acquisition of malignancy is currently unknown. Here, we provide the first evidence that autophagy is essential for o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Min-Jung, Woo, Soo-Jung, Yoon, Chang-Hwan, Lee, Jae-Seong, An, Sungkwan, Choi, Yung-Hyun, Hwang, Sang-Gu, Yoon, Gyesoon, Lee, Su-Jae
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075639/ https://www.ncbi.nlm.nih.gov/pubmed/21300795 http://dx.doi.org/10.1074/jbc.M110.138958

Ejemplares similares

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
por: Lock, Rebecca, et al.
Publicado: (2011)

The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo
por: Rackley, Briana, et al.
Publicado: (2021)

The Role of Wild-Type RAS in Oncogenic RAS Transformation
por: Sheffels, Erin, et al.
Publicado: (2021)

Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes
por: Wang, Shuangshuang, et al.
Publicado: (2021)

Malignant transformation by oncogenic K‐ras requires IDH2‐mediated reductive carboxylation to promote glutamine utilization
por: Liu, Rui, et al.
Publicado: (2022)

Transforming ras oncogenes and multistage carcinogenesis.
por: Balmain, A.
Publicado: (1985)

Mutations of K-ras oncogene in human adrenal tumours in Taiwan.
por: Lin, S. R., et al.
Publicado: (1998)

The human Rgr oncogene is overexpressed in T cell malignancies and induces transformation by acting as a GEF for Ras and Ral
por: Osei-Sarfo, Kwame, et al.
Publicado: (2011)

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma
por: Zhong, Chen, et al.
Publicado: (2019)

Osteopontin is required for full expression of the transformed phenotype by the ras oncogene
por: Wu, Y, et al.
Publicado: (2000)

Requirement for c-ras proteins during viral oncogene transformation
por: Smith, Mark R., et al.
Publicado: (1986)

Acute sensitivity of the oral mucosa to oncogenic K-ras
por: van der Weyden, Louise, et al.
Publicado: (2011)

The Influence of Oncogenic RAS on Chemotherapy and Radiotherapy Resistance Through DNA Repair Pathways
por: Cáceres-Gutiérrez, Rodrigo E., et al.
Publicado: (2022)

Oncogene Ras/Phosphatidylinositol 3-Kinase Signaling Targets Histone H3 Acetylation at Lysine 56
por: Liu, Yan, et al.
Publicado: (2012)

Barriers to horizontal cell transformation by extracellular vesicles containing oncogenic H-ras
por: Lee, Tae Hoon, et al.
Publicado: (2016)

ZEB1 and oncogenic Ras constitute a regulatory switch for stimulus‐dependent E‐cadherin downregulation
por: Otake, Shigeo, et al.
Publicado: (2020)

Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent
por: Morgan, Michael J, et al.
Publicado: (2014)

Teratoma with Malignant Transformation in the Anterior Mediastinum: A Case Report
por: Jung, Jung Im, et al.
Publicado: (2000)

Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity
por: Henkels, Karen M., et al.
Publicado: (2021)

Autophagy buffers Ras-induced genotoxic stress enabling malignant transformation in keratinocytes primed by human papillomavirus
por: Cararo-Lopes, Eduardo, et al.
Publicado: (2021)

Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells
por: Hwang, Sung-Hee, et al.
Publicado: (2022)

Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3
por: Ahn, Sung Yong, et al.
Publicado: (2017)

Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation
por: Kim, Rae-Kwon, et al.
Publicado: (2015)

Establishment and Characterization of Immortalized Miniature Pig Pancreatic Cell Lines Expressing Oncogenic K-Ras(G12D)
por: Yang, Hae-Jun, et al.
Publicado: (2020)

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene
Publicado: (1995)

The Expression of Tumor Rejection Antigen on Rat Fetus Fibroblasts Transformed by the ras Oncogene
por: Okubo, Mamoru, et al.
Publicado: (1988)

K-ras oncogene codon 12 point mutations in testicular cancer.
por: Ridanpää, M, et al.
Publicado: (1993)

Correction: Autophagy buffers Ras-induced genotoxic stress enabling malignant transformation in keratinocytes primed by human papillomavirus
por: Cararo-Lopes, Eduardo, et al.
Publicado: (2021)

Molecular profiles of EGFR, K-ras, c-met, and FGFR in pulmonary pleomorphic carcinoma, a rare lung malignancy
por: Lee, Soohyeon, et al.
Publicado: (2011)

Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated ras peptide
Publicado: (1994)

Activating the Expression of Human K-ras(G12D) Stimulates Oncogenic Transformation in Transgenic Goat Fetal Fibroblast Cells
por: Gong, Jianhua, et al.
Publicado: (2014)

Mitochondrial defect-responsive gene signature in liver-cancer progression
por: Lee, Young-Kyoung, et al.
Publicado: (2015)

Autophagy Is Polarized toward Cell Front during Migration and Spatially Perturbed by Oncogenic Ras
por: Singh, Manish Kumar, et al.
Publicado: (2021)

Akt-mediated Ephexin1–Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation
por: Kim, Jeeho, et al.
Publicado: (2021)

Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence
por: Scaglioni, Pier Paolo, et al.
Publicado: (2012)

Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum.
por: Spandidos, D. A., et al.
Publicado: (1984)

Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation
por: Bettoun, Audrey, et al.
Publicado: (2016)

Oncogenic RAS instructs morphological transformation of human epithelia via differential tissue mechanics
por: Nyga, Agata, et al.
Publicado: (2021)

Dual Oncogenic/Anti-Oncogenic Role of PATZ1 in FRTL5 Rat Thyroid Cells Transformed by the Ha-Ras(V12) Oncogene
por: Vitiello, Michela, et al.
Publicado: (2019)

Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation
por: Toulany, Mahmoud, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_78p8196scrgc72a4djj80po4m4