Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

The prodrug nifurtimox has been used for more than 40 years to treat Chagas disease and forms part of a recently approved combinational therapy that targets West African trypanosomiasis. Despite this, its mode of action is poorly understood. Detection of reactive oxygen and nitrogen intermediates in...

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Detalles Bibliográficos
Autores principales: Hall, Belinda S., Bot, Christopher, Wilkinson, Shane R.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075655/
https://www.ncbi.nlm.nih.gov/pubmed/21345801
http://dx.doi.org/10.1074/jbc.M111.230847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075655/
https://www.ncbi.nlm.nih.gov/pubmed/21345801
http://dx.doi.org/10.1074/jbc.M111.230847

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