Cargando…

Structural Basis for the Inhibition of Human Alkyladenine DNA Glycosylase (AAG) by 3,N(4)-Ethenocytosine-containing DNA

Reactive oxygen and nitrogen species, generated by neutrophils and macrophages in chronically inflamed tissues, readily damage DNA, producing a variety of potentially genotoxic etheno base lesions; such inflammation-related DNA damage is now known to contribute to carcinogenesis. Although the human...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lingaraju, Gondichatnahalli M., Davis, C. Ainsley, Setser, Jeremy W., Samson, Leona D., Drennan, Catherine L.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075667/ https://www.ncbi.nlm.nih.gov/pubmed/21349833 http://dx.doi.org/10.1074/jbc.M110.192435

Ejemplares similares

Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase
por: Setser, Jeremy W., et al.
Publicado: (2011)

Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
por: Montaldo, Nicola P., et al.
Publicado: (2019)

A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein response
por: Milano, Larissa, et al.
Publicado: (2022)

Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1
por: Calvo, Jennifer A., et al.
Publicado: (2013)

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones
por: Longstaff, Colin, et al.
Publicado: (2013)

A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance
por: Song, Ying-Qi, et al.
Publicado: (2023)

Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome
por: Zheng, Lvqin, et al.
Publicado: (2023)

Controllable Autocatalytic Cleavage-Mediated Fluorescence Recovery for Homogeneous Sensing of Alkyladenine DNA Glycosylase from Human Cancer Cells
por: Wang, Li-Juan, et al.
Publicado: (2019)

A single quantum dot-based nanosensor with multilayer of multiple acceptors for ultrasensitive detection of human alkyladenine DNA glycosylase
por: Li, Chen-chen, et al.
Publicado: (2019)

Kinetic Characterization of Single Strand Break Ligation in Duplex DNA by T4 DNA Ligase
por: Lohman, Gregory J. S., et al.
Publicado: (2011)

Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition
por: Alhumaydhi, Fahad A., et al.
Publicado: (2020)

Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase
por: Grell, Tsehai A. J., et al.
Publicado: (2018)

The Naphthoquinone Diospyrin Is an Inhibitor of DNA Gyrase with a Novel Mechanism of Action
por: Karkare, Shantanu, et al.
Publicado: (2013)

The Steric Gate of DNA Polymerase ι Regulates Ribonucleotide Incorporation and Deoxyribonucleotide Fidelity
por: Donigan, Katherine A., et al.
Publicado: (2014)

The Thermodynamic Basis for Viral RNA Detection by the RIG-I Innate Immune Sensor
por: Vela, Adriana, et al.
Publicado: (2012)

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases
por: Sengerová, Blanka, et al.
Publicado: (2012)

Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of β-Aryl Ether Bonds in Lignin
por: Helmich, Kate E., et al.
Publicado: (2016)

Faster Protein Splicing with the Nostoc punctiforme DnaE Intein Using Non-native Extein Residues
por: Cheriyan, Manoj, et al.
Publicado: (2013)

The Roles of Family B and D DNA Polymerases in Thermococcus Species 9°N Okazaki Fragment Maturation
por: Greenough, Lucia, et al.
Publicado: (2015)

ATPase Mechanism of the 5′-3′ DNA Helicase, RecD2: EVIDENCE FOR A PRE-HYDROLYSIS CONFORMATION CHANGE
por: Toseland, Christopher P., et al.
Publicado: (2013)

Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family
por: Schwander, Thomas, et al.
Publicado: (2018)

A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N(4)-ethenocytosine
por: Chaim, Isaac A., et al.
Publicado: (2017)

Pre-steady-state Kinetic Analysis of a Family D DNA Polymerase from Thermococcus sp. 9°N Reveals Mechanisms for Archaeal Genomic Replication and Maintenance
por: Schermerhorn, Kelly M., et al.
Publicado: (2015)

PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase
por: Blazer, Levi L., et al.
Publicado: (2016)

Identification of Human Fumarylacetoacetate Hydrolase Domain-containing Protein 1 (FAHD1) as a Novel Mitochondrial Acylpyruvase
por: Pircher, Haymo, et al.
Publicado: (2011)

The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target β-1,2-Mannosidic Linkages in Candida Mannan
por: Cuskin, Fiona, et al.
Publicado: (2015)

Allosteric Regulation of the Human and Mouse Deoxyribonucleotide Triphosphohydrolase Sterile α-Motif/Histidine-Aspartate Domain-containing Protein 1 (SAMHD1)
por: Miazzi, Cristina, et al.
Publicado: (2014)

Comparative Analysis of Histophilus somni Immunoglobulin-binding Protein A (IbpA) with Other Fic Domain-containing Enzymes Reveals Differences in Substrate and Nucleotide Specificities
por: Mattoo, Seema, et al.
Publicado: (2011)

Structure and Mechanism of the Bifunctional CinA Enzyme from Thermus thermophilus
por: Karuppiah, Vijaykumar, et al.
Publicado: (2014)

Physical Interaction of RECQ5 Helicase with RAD51 Facilitates Its Anti-recombinase Activity
por: Schwendener, Sybille, et al.
Publicado: (2010)

Allostery Wiring Map for Kinesin Energy Transduction and Its Evolution
por: Richard, Jessica, et al.
Publicado: (2016)

Procollagen C-proteinase Enhancer Stimulates Procollagen Processing by Binding to the C-propeptide Region Only
por: Vadon-Le Goff, Sandrine, et al.
Publicado: (2011)

Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Reveals in Vivo Roles in Cellular Homeostasis and Energy Metabolism
por: Wilson, Claire H., et al.
Publicado: (2013)

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase
por: Egger, Sigrid, et al.
Publicado: (2011)

Comparative Kinetic and Functional Characterization of the Motor Domains of Human Nonmuscle Myosin-2C Isoforms
por: Heissler, Sarah M., et al.
Publicado: (2011)

Regulation of Response Regulator Autophosphorylation through Interdomain Contacts
por: Barbieri, Christopher M., et al.
Publicado: (2010)

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY
por: Jin, Zhinan, et al.
Publicado: (2011)

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites
por: Artz, Jennifer D., et al.
Publicado: (2011)

The Catalytic Aspartate Is Protonated in the Michaelis Complex Formed between Trypsin and an in Vitro Evolved Substrate-like Inhibitor: A REFINED MECHANISM OF SERINE PROTEASE ACTION
por: Wahlgren, Weixiao Yuan, et al.
Publicado: (2011)

Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation
por: Singleton, Rachelle S., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ute7o2dbnt83dgab2j1bbj2sek