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Nucleo-cytosolic Shuttling of FoxO1 Directly Regulates Mouse Ins2 but Not Ins1 Gene Expression in Pancreatic Beta Cells (MIN6)

The Forkhead box transcription factor FoxO1 regulates metabolic gene expression in mammals. FoxO1 activity is tightly controlled by phosphatidylinositol 3-kinase (PI3K) signaling, resulting in its phosphorylation and nuclear exclusion. We sought here to determine the mechanisms involved in glucose a...

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Detalles Bibliográficos
Autores principales:	Meur, Gargi, Qian, Qingwen, da Silva Xavier, Gabriela, Pullen, Timothy J., Tsuboi, Takashi, McKinnon, Caroline, Fletcher, Laura, Tavaré, Jeremy M., Hughes, Stephen, Johnson, Paul, Rutter, Guy A.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075709/ https://www.ncbi.nlm.nih.gov/pubmed/21335550 http://dx.doi.org/10.1074/jbc.M110.204248

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