Investigation of solvent effect and NMR shielding tensors of p53 tumor-suppressor gene in drug design

The p53 tumor-suppressor gene encodes a nuclear phosphoprotein with cancer- inhibiting properties. The most probable cancerous mutations occur as point mutations in exons 5 up to 8 of p53, as a base pair substitution that encompasses CUA and GAT sequences. As DNA drug design represents a direct gene...

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Detalles Bibliográficos
Autores principales: Irani, S, Monajjemi, M, Honarparvar, B, Atyabi, SM, Sadeghizadeh, M
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075894/
https://www.ncbi.nlm.nih.gov/pubmed/21499418
http://dx.doi.org/10.2147/IJN.S14632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075894/
https://www.ncbi.nlm.nih.gov/pubmed/21499418
http://dx.doi.org/10.2147/IJN.S14632

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