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Investigation of solvent effect and NMR shielding tensors of p53 tumor-suppressor gene in drug design
The p53 tumor-suppressor gene encodes a nuclear phosphoprotein with cancer- inhibiting properties. The most probable cancerous mutations occur as point mutations in exons 5 up to 8 of p53, as a base pair substitution that encompasses CUA and GAT sequences. As DNA drug design represents a direct gene...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075894/ https://www.ncbi.nlm.nih.gov/pubmed/21499418 http://dx.doi.org/10.2147/IJN.S14632 |