Auditory Cortex Spatial Sensitivity Sharpens During Task Performance

Activity in the primary auditory cortex (A1) is known to be essential for normal sound localization behavior, yet previous studies of the spatial sensitivity of neurons in A1 have found surprisingly broad spatial tuning. We tested the hypothesis that spatial tuning sharpens when an animal engages in an auditory task. Cats performed a task that required evaluation of the locations of sounds and another that required active listening but in which sound location was irrelevant. Some 26–44% of the units recorded in A1 showed significantly sharpened spatial tuning during the behavioral tasks compared to idle conditions, with greatest sharpening during the location-relevant task. Spatial sharpening occurred on a scale of tens of seconds and could be replicated multiple times within ~1.5-hr test sessions. Sharpening resulted primarily from increased suppression of responses to sounds at least-preferred locations. That and an observed increase in latencies suggest an important role of inhibitory mechanisms.