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Brinzolamide-timolol suspension: acceptability and side effect profile

BACKGROUND: This study aimed to determine the frequency, nature, and impact of side effects associated with the use of brinzolamide-timolol suspension, a topical ocular antihypertensive preparation. METHODS: A questionnaire was distributed to 76 consecutive patients attending the Sunderland Eye Infi...

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Detalles Bibliográficos
Autores principales: Doherty, MD, Fraser, SG, Phelan, PS
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076117/
https://www.ncbi.nlm.nih.gov/pubmed/21499567
http://dx.doi.org/10.2147/OPTH.S18251
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author Doherty, MD
Fraser, SG
Phelan, PS
author_facet Doherty, MD
Fraser, SG
Phelan, PS
author_sort Doherty, MD
collection PubMed
description BACKGROUND: This study aimed to determine the frequency, nature, and impact of side effects associated with the use of brinzolamide-timolol suspension, a topical ocular antihypertensive preparation. METHODS: A questionnaire was distributed to 76 consecutive patients attending the Sunderland Eye Infirmary Glaucoma Service who were using the brinzolamide-timolol suspension. The questions related specifically to effects on daily life, blurring of vision, stinging, irritation, and acceptability compared with any drops previously used. Respondents were asked to grade their answers to these questions using a numerical scale from 0 to 10. RESULTS: Seventy-six patients (100%) responded, comprising 58 females and 18 males, aged 68–95 years, treated for 3–7 months. Quality of life was not significantly affected, with the majority of patients recording a response between 0 and 2. Visual blurring was a more prominent feature, with the most common scores being 3 and 4. Stinging did not appear to be a prominent feature, with 0 as the most common response. Similarly, irritation was not a common finding, with most respondents scoring 0 and 1. Finally, the brinzolamide-timolol suspension compared favorably with previously used drops, with the vast majority of patients expressing a preference for this suspension over other topical medications. CONCLUSION: Brinzolamide-timolol suspension appears to be a well tolerated and acceptable medication, with minimal effect on patient quality of life.
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spelling pubmed-30761172011-04-15 Brinzolamide-timolol suspension: acceptability and side effect profile Doherty, MD Fraser, SG Phelan, PS Clin Ophthalmol Original Research BACKGROUND: This study aimed to determine the frequency, nature, and impact of side effects associated with the use of brinzolamide-timolol suspension, a topical ocular antihypertensive preparation. METHODS: A questionnaire was distributed to 76 consecutive patients attending the Sunderland Eye Infirmary Glaucoma Service who were using the brinzolamide-timolol suspension. The questions related specifically to effects on daily life, blurring of vision, stinging, irritation, and acceptability compared with any drops previously used. Respondents were asked to grade their answers to these questions using a numerical scale from 0 to 10. RESULTS: Seventy-six patients (100%) responded, comprising 58 females and 18 males, aged 68–95 years, treated for 3–7 months. Quality of life was not significantly affected, with the majority of patients recording a response between 0 and 2. Visual blurring was a more prominent feature, with the most common scores being 3 and 4. Stinging did not appear to be a prominent feature, with 0 as the most common response. Similarly, irritation was not a common finding, with most respondents scoring 0 and 1. Finally, the brinzolamide-timolol suspension compared favorably with previously used drops, with the vast majority of patients expressing a preference for this suspension over other topical medications. CONCLUSION: Brinzolamide-timolol suspension appears to be a well tolerated and acceptable medication, with minimal effect on patient quality of life. Dove Medical Press 2011 2011-03-31 /pmc/articles/PMC3076117/ /pubmed/21499567 http://dx.doi.org/10.2147/OPTH.S18251 Text en © 2011 Doherty et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Doherty, MD
Fraser, SG
Phelan, PS
Brinzolamide-timolol suspension: acceptability and side effect profile
title Brinzolamide-timolol suspension: acceptability and side effect profile
title_full Brinzolamide-timolol suspension: acceptability and side effect profile
title_fullStr Brinzolamide-timolol suspension: acceptability and side effect profile
title_full_unstemmed Brinzolamide-timolol suspension: acceptability and side effect profile
title_short Brinzolamide-timolol suspension: acceptability and side effect profile
title_sort brinzolamide-timolol suspension: acceptability and side effect profile
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076117/
https://www.ncbi.nlm.nih.gov/pubmed/21499567
http://dx.doi.org/10.2147/OPTH.S18251
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