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Anastrozole-related acute hepatitis with autoimmune features: a case report
BACKGROUND: Two cases of acute hepatitis occurring during treatment with anastrozole have previously been reported, but the underlying mechanisms of liver injury are still uncertain. We report the case of anastrozole-related acute hepatitis with some autoimmune features. CASE PRESENTATION: A 70-year...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076249/ https://www.ncbi.nlm.nih.gov/pubmed/21453541 http://dx.doi.org/10.1186/1471-230X-11-32 |
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author | Inno, Alessandro Basso, Michele Vecchio, Fabio M Marsico, Valentina A Cerchiaro, Eleonora D'Argento, Ettore Bagalà, Cinzia Barone, Carlo |
author_facet | Inno, Alessandro Basso, Michele Vecchio, Fabio M Marsico, Valentina A Cerchiaro, Eleonora D'Argento, Ettore Bagalà, Cinzia Barone, Carlo |
author_sort | Inno, Alessandro |
collection | PubMed |
description | BACKGROUND: Two cases of acute hepatitis occurring during treatment with anastrozole have previously been reported, but the underlying mechanisms of liver injury are still uncertain. We report the case of anastrozole-related acute hepatitis with some autoimmune features. CASE PRESENTATION: A 70-year-old woman developed acute hepatitis associated with serum antinuclear antibodies during anastrozole treatment; after drug withdrawal, liver function parameters rapidly improved and serum auto-antibodies were no longer detectable. CONCLUSIONS: Anastrozole-induced hepatotoxicity is a very rare event. Drug-drug interactions or metabolically-mediated damage might be involved, with a possible role of individual susceptibility. Our report suggests that an immune-mediated mechanism may also be considered in anastrozole-related liver injury. |
format | Text |
id | pubmed-3076249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30762492011-04-14 Anastrozole-related acute hepatitis with autoimmune features: a case report Inno, Alessandro Basso, Michele Vecchio, Fabio M Marsico, Valentina A Cerchiaro, Eleonora D'Argento, Ettore Bagalà, Cinzia Barone, Carlo BMC Gastroenterol Case Report BACKGROUND: Two cases of acute hepatitis occurring during treatment with anastrozole have previously been reported, but the underlying mechanisms of liver injury are still uncertain. We report the case of anastrozole-related acute hepatitis with some autoimmune features. CASE PRESENTATION: A 70-year-old woman developed acute hepatitis associated with serum antinuclear antibodies during anastrozole treatment; after drug withdrawal, liver function parameters rapidly improved and serum auto-antibodies were no longer detectable. CONCLUSIONS: Anastrozole-induced hepatotoxicity is a very rare event. Drug-drug interactions or metabolically-mediated damage might be involved, with a possible role of individual susceptibility. Our report suggests that an immune-mediated mechanism may also be considered in anastrozole-related liver injury. BioMed Central 2011-03-31 /pmc/articles/PMC3076249/ /pubmed/21453541 http://dx.doi.org/10.1186/1471-230X-11-32 Text en Copyright ©2011 Inno et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Inno, Alessandro Basso, Michele Vecchio, Fabio M Marsico, Valentina A Cerchiaro, Eleonora D'Argento, Ettore Bagalà, Cinzia Barone, Carlo Anastrozole-related acute hepatitis with autoimmune features: a case report |
title | Anastrozole-related acute hepatitis with autoimmune features: a case report |
title_full | Anastrozole-related acute hepatitis with autoimmune features: a case report |
title_fullStr | Anastrozole-related acute hepatitis with autoimmune features: a case report |
title_full_unstemmed | Anastrozole-related acute hepatitis with autoimmune features: a case report |
title_short | Anastrozole-related acute hepatitis with autoimmune features: a case report |
title_sort | anastrozole-related acute hepatitis with autoimmune features: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076249/ https://www.ncbi.nlm.nih.gov/pubmed/21453541 http://dx.doi.org/10.1186/1471-230X-11-32 |
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