Pre-Existing Adenovirus Immunity Modifies a Complex Mixed Th1 and Th2 Cytokine Response to an Ad5/HIV-1 Vaccine Candidate in Humans

The results of the recent Step Study highlight a need to clarify the effects of pre-existing natural immunity to a vaccine vector on vaccine-induced T-cell responses. To investigate this interaction, we examined the relationship between pre-existing Ad5 immunity and T-cell cytokine response profiles...

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Detalles Bibliográficos
Autores principales: Pine, Samuel O., Kublin, James G., Hammer, Scott M., Borgerding, Joleen, Huang, Yunda, Casimiro, Danilo R., McElrath, M. Juliana
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076372/
https://www.ncbi.nlm.nih.gov/pubmed/21533229
http://dx.doi.org/10.1371/journal.pone.0018526

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