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Binge-Pattern Alcohol Exposure during Puberty Induces Long-Term Changes in HPA Axis Reactivity

Adolescence is a dynamic and important period of brain development however, little is known about the long-term neurobiological consequences of alcohol consumption during puberty. Our previous studies showed that binge-pattern ethanol (EtOH) treatment during pubertal development negatively dysregula...

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Autores principales: Przybycien-Szymanska, Magdalena M., Mott, Natasha N., Paul, Caitlin R., Gillespie, Roberta A., Pak, Toni R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076381/
https://www.ncbi.nlm.nih.gov/pubmed/21533237
http://dx.doi.org/10.1371/journal.pone.0018350
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author Przybycien-Szymanska, Magdalena M.
Mott, Natasha N.
Paul, Caitlin R.
Gillespie, Roberta A.
Pak, Toni R.
author_facet Przybycien-Szymanska, Magdalena M.
Mott, Natasha N.
Paul, Caitlin R.
Gillespie, Roberta A.
Pak, Toni R.
author_sort Przybycien-Szymanska, Magdalena M.
collection PubMed
description Adolescence is a dynamic and important period of brain development however, little is known about the long-term neurobiological consequences of alcohol consumption during puberty. Our previous studies showed that binge-pattern ethanol (EtOH) treatment during pubertal development negatively dysregulated the responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis, as manifested by alterations in corticotrophin-releasing hormone (CRH), arginine vasopressin (AVP), and corticosterone (CORT) during this time period. Thus, the primary goal of this study was to determine whether these observed changes in important central regulators of the stress response were permanent or transient. In this study, juvenile male Wistar rats were treated with a binge-pattern EtOH treatment paradigm or saline alone for 8 days. The animals were left undisturbed until adulthood when they received a second round of treatments consisting of saline alone, a single dose of EtOH, or a second binge-pattern treatment paradigm. The results showed that pubertal binge-pattern EtOH exposure induced striking long-lasting alterations of many HPA axis parameters. Overall, our data provide strong evidence that binge-pattern EtOH exposure during pubertal maturation has long-term detrimental effects for the healthy development of the HPA axis.
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spelling pubmed-30763812011-04-29 Binge-Pattern Alcohol Exposure during Puberty Induces Long-Term Changes in HPA Axis Reactivity Przybycien-Szymanska, Magdalena M. Mott, Natasha N. Paul, Caitlin R. Gillespie, Roberta A. Pak, Toni R. PLoS One Research Article Adolescence is a dynamic and important period of brain development however, little is known about the long-term neurobiological consequences of alcohol consumption during puberty. Our previous studies showed that binge-pattern ethanol (EtOH) treatment during pubertal development negatively dysregulated the responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis, as manifested by alterations in corticotrophin-releasing hormone (CRH), arginine vasopressin (AVP), and corticosterone (CORT) during this time period. Thus, the primary goal of this study was to determine whether these observed changes in important central regulators of the stress response were permanent or transient. In this study, juvenile male Wistar rats were treated with a binge-pattern EtOH treatment paradigm or saline alone for 8 days. The animals were left undisturbed until adulthood when they received a second round of treatments consisting of saline alone, a single dose of EtOH, or a second binge-pattern treatment paradigm. The results showed that pubertal binge-pattern EtOH exposure induced striking long-lasting alterations of many HPA axis parameters. Overall, our data provide strong evidence that binge-pattern EtOH exposure during pubertal maturation has long-term detrimental effects for the healthy development of the HPA axis. Public Library of Science 2011-04-13 /pmc/articles/PMC3076381/ /pubmed/21533237 http://dx.doi.org/10.1371/journal.pone.0018350 Text en Przybycien-Szymanska et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Przybycien-Szymanska, Magdalena M.
Mott, Natasha N.
Paul, Caitlin R.
Gillespie, Roberta A.
Pak, Toni R.
Binge-Pattern Alcohol Exposure during Puberty Induces Long-Term Changes in HPA Axis Reactivity
title Binge-Pattern Alcohol Exposure during Puberty Induces Long-Term Changes in HPA Axis Reactivity
title_full Binge-Pattern Alcohol Exposure during Puberty Induces Long-Term Changes in HPA Axis Reactivity
title_fullStr Binge-Pattern Alcohol Exposure during Puberty Induces Long-Term Changes in HPA Axis Reactivity
title_full_unstemmed Binge-Pattern Alcohol Exposure during Puberty Induces Long-Term Changes in HPA Axis Reactivity
title_short Binge-Pattern Alcohol Exposure during Puberty Induces Long-Term Changes in HPA Axis Reactivity
title_sort binge-pattern alcohol exposure during puberty induces long-term changes in hpa axis reactivity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076381/
https://www.ncbi.nlm.nih.gov/pubmed/21533237
http://dx.doi.org/10.1371/journal.pone.0018350
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