Improved outcome following allogeneic stem cell transplantation in chronic myeloid leukemia is associated with higher expression of BMI-1 and immune responses to BMI-1 protein

BMI-1 and EZH2 are polycomb group (PcG) proteins which maintain self-renewal of stem cells, and are overexpressed in leukemia. To investigate the potential of PcG proteins as leukemia-associated antigens, and targets for graft-versus-leukemia (GVL) effects, we studied cells from 86 chronic myeloid l...

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Detalles Bibliográficos
Autores principales: Yong, Agnes S.M., Stephens, Nicole, Weber, Gerrit, Li, Yixin, Savani, Bipin N., Eniafe, Rhoda, Keyvanfar, Keyvan, Kurlander, Roger, Rezvani, Katayoun, Barrett, A. John
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076540/
https://www.ncbi.nlm.nih.gov/pubmed/21252986
http://dx.doi.org/10.1038/leu.2010.325

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