A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder

We conducted a pilot randomized controlled trial to determine the feasibility and initial safety and efficacy of omega-3 fatty acids (1.3 g/day) for the treatment of hyperactivity in 27 children ages 3–8 with autism spectrum disorder (ASD). After 12 weeks, hyperactivity, as measured by the Aberrant...

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Detalles Bibliográficos
Autores principales: Bent, Stephen, Bertoglio, Kiah, Ashwood, Paul, Bostrom, Alan, Hendren, Robert L.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076562/
https://www.ncbi.nlm.nih.gov/pubmed/20683766
http://dx.doi.org/10.1007/s10803-010-1078-8
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author Bent, Stephen
Bertoglio, Kiah
Ashwood, Paul
Bostrom, Alan
Hendren, Robert L.
author_facet Bent, Stephen
Bertoglio, Kiah
Ashwood, Paul
Bostrom, Alan
Hendren, Robert L.
author_sort Bent, Stephen
collection PubMed
description We conducted a pilot randomized controlled trial to determine the feasibility and initial safety and efficacy of omega-3 fatty acids (1.3 g/day) for the treatment of hyperactivity in 27 children ages 3–8 with autism spectrum disorder (ASD). After 12 weeks, hyperactivity, as measured by the Aberrant Behavior Checklist, improved 2.7 (±4.8) points in the omega-3 group compared to 0.3 (±7.2) points in the placebo group (p = 0.40; effect size = 0.38). Correlations were found between decreases in five fatty acid levels and decreases in hyperactivity, and the treatment was well tolerated. Although this pilot study did not find a statistically significant benefit from omega-3 fatty acids, the small sample size does not rule out small to moderate beneficial effects.
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spelling pubmed-30765622011-05-23 A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder Bent, Stephen Bertoglio, Kiah Ashwood, Paul Bostrom, Alan Hendren, Robert L. J Autism Dev Disord Original Paper We conducted a pilot randomized controlled trial to determine the feasibility and initial safety and efficacy of omega-3 fatty acids (1.3 g/day) for the treatment of hyperactivity in 27 children ages 3–8 with autism spectrum disorder (ASD). After 12 weeks, hyperactivity, as measured by the Aberrant Behavior Checklist, improved 2.7 (±4.8) points in the omega-3 group compared to 0.3 (±7.2) points in the placebo group (p = 0.40; effect size = 0.38). Correlations were found between decreases in five fatty acid levels and decreases in hyperactivity, and the treatment was well tolerated. Although this pilot study did not find a statistically significant benefit from omega-3 fatty acids, the small sample size does not rule out small to moderate beneficial effects. Springer US 2010-08-04 2011 /pmc/articles/PMC3076562/ /pubmed/20683766 http://dx.doi.org/10.1007/s10803-010-1078-8 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Paper
Bent, Stephen
Bertoglio, Kiah
Ashwood, Paul
Bostrom, Alan
Hendren, Robert L.
A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder
title A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder
title_full A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder
title_fullStr A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder
title_full_unstemmed A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder
title_short A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder
title_sort pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076562/
https://www.ncbi.nlm.nih.gov/pubmed/20683766
http://dx.doi.org/10.1007/s10803-010-1078-8
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