Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models

Gemcitabine is a deoxycytidine (dCyd) analog with activity in leukemia and solid tumors, which requires phosphorylation by deoxycytidine kinase (dCK). Decreased membrane transport is a mechanism of resistance to gemcitabine. In order to facilitate gemcitabine uptake and prolong retention in the cell...

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Detalles Bibliográficos
Autores principales: Bergman, Andries M., Adema, Auke D., Balzarini, Jan, Bruheim, Skjalg, Fichtner, Iduna, Noordhuis, Paul, Fodstad, Øystein, Myhren, Finn, Sandvold, Marit L., Hendriks, Hans R., Peters, Godefridus J.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076580/
https://www.ncbi.nlm.nih.gov/pubmed/20066470
http://dx.doi.org/10.1007/s10637-009-9377-7

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