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Cardiac glycosides are potent inhibitors of interferon-β gene expression

We report that bufalin and other cardiac glycoside inhibitors of the sodium-potassium ATPase (sodium pump) potently inhibit the induction of the interferon-β (IFNβ) gene by virus, dsRNA or dsDNA. Cardiac glycosides increase the intracellular sodium concentration, which appears to inhibit the ATPase...

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Detalles Bibliográficos
Autores principales: Ye, Junqiang, Chen, Shuibing, Maniatis, Tom
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076628/
https://www.ncbi.nlm.nih.gov/pubmed/21076398
http://dx.doi.org/10.1038/nchembio.476

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