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Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation
Accurate chromosome segregation depends on biorientation, whereby sister chromatids attach to microtubules emanating from opposite spindle poles. The spindle assembly checkpoint is a conserved surveillance mechanism in eukaryotes that inhibits anaphase onset until all chromosomes are bioriented1, 2,...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076698/ https://www.ncbi.nlm.nih.gov/pubmed/21394085 http://dx.doi.org/10.1038/ncb2223 |