Cargando…

A whole organism screen identifies novel regulators of fat storage

The regulation of energy homeostasis integrates diverse biological processes ranging from behavior to metabolism and is linked fundamentally to numerous disease states. To identify new molecules that can bypass homeostatic compensatory mechanisms of energy balance in intact animals, we screened for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lemieux, George A., Liu, Jason, Mayer, Nasima, Bainton, Roland J., Ashrafi, Kaveh, Werb, Zena
Formato:	Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076723/ https://www.ncbi.nlm.nih.gov/pubmed/21390037 http://dx.doi.org/10.1038/nchembio.534

Ejemplares similares

In Silico Molecular Comparisons of C. elegans and Mammalian Pharmacology Identify Distinct Targets That Regulate Feeding
por: Lemieux, George A., et al.
Publicado: (2013)

Stressing about misplaced fat is a key to longevity
por: Lemieux, George A, et al.
Publicado: (2015)

Rictor/TORC2 Regulates Caenorhabditis elegans Fat Storage, Body Size, and Development through sgk-1
por: Jones, Kevin T, et al.
Publicado: (2009)

The Joy of a Career in Cell Biology
por: Werb, Zena
Publicado: (2010)

A new trauma frontier: Exploratory pilot study of platelet transcriptomics in trauma patients
por: Fields, Alexander T., et al.
Publicado: (2022)

Kynurenic acid accumulation underlies learning and memory impairment associated with aging
por: Vohra, Mihir, et al.
Publicado: (2018)

The beneficial effects of dietary restriction on learning are distinct from its effects on longevity and mediated by depletion of a neuroinhibitory metabolite
por: Vohra, Mihir, et al.
Publicado: (2017)

Identifying lipid particle sub-types in live Caenorhabditis elegans with two-photon fluorescence lifetime imaging
por: Chen, Wei-Wen, et al.
Publicado: (2023)

Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases
por: Werner, Erica, et al.
Publicado: (2002)

A Pair of Dopamine Neurons Target the D1-Like Dopamine Receptor DopR in the Central Complex to Promote Ethanol-Stimulated Locomotion in Drosophila
por: Kong, Eric C., et al.
Publicado: (2010)

Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism
por: Gut, Philipp, et al.
Publicado: (2012)

C. elegans screen for modulators of fat storage
Publicado: (2011)

CHOLESTEROL METABOLISM IN THE MACROPHAGE : I. THE REGULATION OF CHOLESTEROL EXCHANGE
por: Werb, Zena, et al.
Publicado: (1971)

CHOLESTEROL METABOLISM IN THE MACROPHAGE : II. ALTERATION OF SUBCELLULAR EXCHANGEABLE CHOLESTEROL COMPARTMENTS AND EXCHANGE IN OTHER CELL TYPES
por: Werb, Zena, et al.
Publicado: (1971)

CHOLESTEROL METABOLISM IN THE MACROPHAGE : III. INGESTION AND INTRACELLULAR FATE OF CHOLESTEROL AND CHOLESTEROL ESTERS
por: Werb, Zena, et al.
Publicado: (1972)

STIMULATION BY ENDOCYTOSIS OF THE SECRETION OF COLLAGENASE AND NEUTRAL PROTEINASE FROM RABBIT SYNOVIAL FIBROBLASTS
por: Werb, Zena, et al.
Publicado: (1974)

Inflammatory Cells and Cancer: Think Different!
por: Coussens, Lisa M., et al.
Publicado: (2001)

The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein–coupled receptors
por: Yan, Yibing, et al.
Publicado: (2002)

Roles of the immune system in cancer: from tumor initiation to metastatic progression
por: Gonzalez, Hugo, et al.
Publicado: (2018)

Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter
por: Lin, Lin, et al.
Publicado: (2020)

The extracellular matrix: A dynamic niche in cancer progression
por: Lu, Pengfei, et al.
Publicado: (2012)

Matrix metalloproteinases in stem cell regulation and cancer
por: Kessenbrock, Kai, et al.
Publicado: (2015)

Whole Organism High Content Screening Identifies Stimulators of Pancreatic Beta-Cell Proliferation
por: Tsuji, Naoki, et al.
Publicado: (2014)

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes
por: Fata, Jimmie E, et al.
Publicado: (2004)

Stromelysin-1 Regulates Adipogenesis during Mammary Gland Involution
por: Alexander, Caroline M., et al.
Publicado: (2001)

Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer
por: Takai, Ken, et al.
Publicado: (2016)

Lmo Mutants Reveal a Novel Role for Circadian Pacemaker Neurons in Cocaine-Induced Behaviors
por: Tsai, Linus T.-Y, et al.
Publicado: (2004)

Defective fat storage
por: Williams, Ruth
Publicado: (2006)

A Buoyancy-Based Screen of Drosophila Larvae for Fat-Storage Mutants Reveals a Role for Sir2 in Coupling Fat Storage to Nutrient Availability
por: Reis, Tânia, et al.
Publicado: (2010)

Christendom : a short history of Christianity and its impact on Western civilization /
por: Bainton, Roland Herbert, 1894-1984
Publicado: (1966)

Concepts of extracellular matrix remodelling in tumour progression and metastasis
por: Winkler, Juliane, et al.
Publicado: (2020)

Application value of whole exome sequencing in screening and identifying novel mutations of hypopharyngeal cancer
por: Yao, Jingwei, et al.
Publicado: (2023)

Cell biology of fat storage
por: Cohen, Paul, et al.
Publicado: (2016)

Barrier mechanisms in the Drosophila blood-brain barrier
por: Hindle, Samantha J., et al.
Publicado: (2014)

Basement Membrane and Repair of Injury to Peripheral Nerve: Defining a Potential Role for Macrophages, Matrix Metalloproteinases, and Tissue Inhibitor of Metalloproteinases-1
por: Fleur, Monique La, et al.
Publicado: (1996)

A Whole Genome-Wide Arrayed CRISPR Screen in Primary Organ Fibroblasts to Identify Regulators of Kidney Fibrosis
por: Turner, Robert J., et al.
Publicado: (2020)

High-Throughput Screening of Mouse Gene Knockouts Identifies Established and Novel High Body Fat Phenotypes
por: Powell, David R, et al.
Publicado: (2021)

Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells
por: Lochter, André, et al.
Publicado: (1997)

Whole-genome sequencing reveals sex determination and liver high-fat storage mechanisms of yellowstripe goby (Mugilogobius chulae)
por: Cai, Lei, et al.
Publicado: (2021)

Zebrafish: An emerging whole-organism screening tool in safety pharmacology
por: Nikam, Vandana S., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7ar0f56ksup9bg6cukdfl7dgg5