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Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation
Several mechanisms have been proposed for the synthesis of substrate-linked ubiquitin chains. HECT ligases directly catalyse protein ubiquitination and have been found to non-covalently interact with ubiquitin. We report crystal structures of the Nedd4 HECT domain, alone and in complex with ubiquiti...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
European Molecular Biology Organization
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077247/ https://www.ncbi.nlm.nih.gov/pubmed/21399620 http://dx.doi.org/10.1038/embor.2011.21 |