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Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain

USP4 is a member of the ubiquitin-specific protease (USP) family of deubiquitinating enzymes that has a role in spliceosome regulation. Here, we show that the crystal structure of the minimal catalytic domain of USP4 has the conserved USP-like fold with its typical ubiquitin-binding site. A ubiquiti...

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Detalles Bibliográficos
Autores principales: Luna-Vargas, Mark P A, Faesen, Alex C, van Dijk, Willem J, Rape, Michael, Fish, Alexander, Sixma, Titia K
Formato: Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077250/
https://www.ncbi.nlm.nih.gov/pubmed/21415856
http://dx.doi.org/10.1038/embor.2011.33

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