CO(2) exacerbates oxygen toxicity

Reactive oxygen species (ROS) are harmful because they can oxidize biological macromolecules. We show here that atmospheric CO(2) (concentration range studied: 40–1,000 p.p.m.) increases death rates due to H(2)O(2) stress in Escherichia coli in a dose-specific manner. This effect is correlated with...

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Autores principales: Ezraty, Benjamin, Chabalier, Maïalène, Ducret, Adrien, Maisonneuve, Etienne, Dukan, Sam
Formato: Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077260/
https://www.ncbi.nlm.nih.gov/pubmed/21350502
http://dx.doi.org/10.1038/embor.2011.7
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author Ezraty, Benjamin
Chabalier, Maïalène
Ducret, Adrien
Maisonneuve, Etienne
Dukan, Sam
author_facet Ezraty, Benjamin
Chabalier, Maïalène
Ducret, Adrien
Maisonneuve, Etienne
Dukan, Sam
author_sort Ezraty, Benjamin
collection PubMed
description Reactive oxygen species (ROS) are harmful because they can oxidize biological macromolecules. We show here that atmospheric CO(2) (concentration range studied: 40–1,000 p.p.m.) increases death rates due to H(2)O(2) stress in Escherichia coli in a dose-specific manner. This effect is correlated with an increase in H(2)O(2)-induced mutagenesis and, as shown by 8-oxo-guanine determinations in cells, DNA base oxidation rates. Moreover, the survival of mutants that are sensitive to aerobic conditions (Hpx(−) dps and recA fur), presumably because of their inability to tolerate ROS, seems to depend on CO(2) concentration. Thus, CO(2) exacerbates ROS toxicity by increasing oxidative cellular lesions.
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spelling pubmed-30772602011-05-27 CO(2) exacerbates oxygen toxicity Ezraty, Benjamin Chabalier, Maïalène Ducret, Adrien Maisonneuve, Etienne Dukan, Sam EMBO Rep Scientific Reports Reactive oxygen species (ROS) are harmful because they can oxidize biological macromolecules. We show here that atmospheric CO(2) (concentration range studied: 40–1,000 p.p.m.) increases death rates due to H(2)O(2) stress in Escherichia coli in a dose-specific manner. This effect is correlated with an increase in H(2)O(2)-induced mutagenesis and, as shown by 8-oxo-guanine determinations in cells, DNA base oxidation rates. Moreover, the survival of mutants that are sensitive to aerobic conditions (Hpx(−) dps and recA fur), presumably because of their inability to tolerate ROS, seems to depend on CO(2) concentration. Thus, CO(2) exacerbates ROS toxicity by increasing oxidative cellular lesions. European Molecular Biology Organization 2011-04-01 2011-02-25 /pmc/articles/PMC3077260/ /pubmed/21350502 http://dx.doi.org/10.1038/embor.2011.7 Text en Copyright © 2011, European Molecular Biology Organization https://creativecommons.org/licenses/by-nc-sa/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Scientific Reports
Ezraty, Benjamin
Chabalier, Maïalène
Ducret, Adrien
Maisonneuve, Etienne
Dukan, Sam
CO(2) exacerbates oxygen toxicity
title CO(2) exacerbates oxygen toxicity
title_full CO(2) exacerbates oxygen toxicity
title_fullStr CO(2) exacerbates oxygen toxicity
title_full_unstemmed CO(2) exacerbates oxygen toxicity
title_short CO(2) exacerbates oxygen toxicity
title_sort co(2) exacerbates oxygen toxicity
topic Scientific Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077260/
https://www.ncbi.nlm.nih.gov/pubmed/21350502
http://dx.doi.org/10.1038/embor.2011.7
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AT ducretadrien co2exacerbatesoxygentoxicity
AT maisonneuveetienne co2exacerbatesoxygentoxicity
AT dukansam co2exacerbatesoxygentoxicity

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