Cargando…

WRAP53 promotes cancer cell survival and is a potential target for cancer therapy

We previously identified WRAP53 as an antisense transcript that regulates the p53 tumor suppressor. The WRAP53 gene also encodes a protein essential for Cajal body formation and involved in cellular trafficking of the survival of motor neuron complex, the telomerase enzyme and small Cajal body-speci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mahmoudi, S, Henriksson, S, Farnebo, L, Roberg, K, Farnebo, M
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077286/ https://www.ncbi.nlm.nih.gov/pubmed/21368886 http://dx.doi.org/10.1038/cddis.2010.90

Ejemplares similares

On the road with WRAP53β: guardian of Cajal bodies and genome integrity
por: Henriksson, Sofia, et al.
Publicado: (2015)

WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies
por: Mahmoudi, Salah, et al.
Publicado: (2010)

Correction: WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies
por: Mahmoudi, Salah, et al.
Publicado: (2018)

Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response
por: Coucoravas, Christos, et al.
Publicado: (2016)

Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks
por: Rassoolzadeh, H, et al.
Publicado: (2016)

WRAP53β, survivin and p16(INK4a) expression as potential predictors of radiotherapy/chemoradiotherapy response in T2N0-T3N0 glottic laryngeal cancer
por: Tiefenböck-Hansson, Katharina, et al.
Publicado: (2017)

Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome
por: Hedström, E, et al.
Publicado: (2015)

The Cajal Body Protein WRAP53β Prepares the Scene for Repair of DNA Double-Strand Breaks by Regulating Local Ubiquitination
por: Bergstrand, Sofie, et al.
Publicado: (2019)

The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair
por: Henriksson, Sofia, et al.
Publicado: (2014)

The Sub-Cellular Localization of WRAP53 Has Prognostic Impact in Breast Cancer
por: Silwal-Pandit, Laxmi, et al.
Publicado: (2015)

The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1
por: Rassoolzadeh, Hanif, et al.
Publicado: (2016)

Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal–Hreidarsson syndrome
por: Bergstrand, Sofie, et al.
Publicado: (2020)

Evaluation of dyskerin expression and the Cajal body protein WRAP53β as potential prognostic markers for patients with primary vaginal carcinoma
por: Ranhem, Cecilia, et al.
Publicado: (2022)

The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer
por: Melissaridou, Styliani, et al.
Publicado: (2019)

Low levels of WRAP53 predict decreased efficacy of radiotherapy and are prognostic for local recurrence and death from breast cancer: a long‐term follow‐up of the SweBCG91RT randomized trial
por: Egelberg, Moa, et al.
Publicado: (2023)

Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke
por: Sánchez-Morán, Irene, et al.
Publicado: (2020)

Volumetric FDG-PET predicts overall and progression- free survival after 14 days of targeted therapy in metastatic renal cell carcinoma
por: Farnebo, Jacob, et al.
Publicado: (2014)

Midface Osteotomies for Feminization of the Facial Skeleton
por: Lundgren, T. Kalle, et al.
Publicado: (2017)

RNF8 - The Achilles heel of DNA repair when splicing rules
por: Pederiva, Chiara, et al.
Publicado: (2018)

The Role of WRAP53 in Cell Homeostasis and Carcinogenesis Onset
por: Gadelha, Renan Brito, et al.
Publicado: (2022)

Progression-free and overall survival in metastatic castration-resistant prostate cancer treated with abiraterone acetate can be predicted with serial C11-acetate PET/CT
por: Farnebo, Jacob, et al.
Publicado: (2016)

Promoter methylation of Wrap53α, an antisense transcript of p53, is associated with the poor prognosis of patients with non-small cell lung cancer
por: Kim, Dong Sun, et al.
Publicado: (2018)

A Nordic survey of the management of palliative care in patients with head and neck cancer
por: Boëthius, Helena, et al.
Publicado: (2020)

Haplotype and linkage disequilibrium of TP53-WRAP53 locus in Iranian-Azeri women with breast cancer
por: Pouladi, Nasser, et al.
Publicado: (2019)

Association of common WRAP 53 variant with ovarian cancer risk in the Polish population
por: Mędrek, Krzysztof, et al.
Publicado: (2012)

Incidence of distal ulna fractures in a Swedish county: 74/100,000 person-years, most of them treated non-operatively
por: Moloney, Maria, et al.
Publicado: (2019)

Distal ulna fractures in adults—subcapitular, transverse fractures did not benefit from surgical treatment
por: Moloney, Maria, et al.
Publicado: (2022)

Membrane-wrapped nanoparticles for photothermal cancer therapy
por: Aboeleneen, Sara B., et al.
Publicado: (2022)

Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors
por: Zhu, Yan, et al.
Publicado: (2023)

Inhibition of Parathyroid Hormone Secretion by Caffeine in Human Parathyroid Cells
por: Lu, Ming, et al.
Publicado: (2013)

Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study
por: Talani, Charbél, et al.
Publicado: (2019)

Oncogenic Activity of Wrap53 in Human Colorectal Cancer In Vitro and in Nude Mouse Xenografts
por: Zhu, Yu, et al.
Publicado: (2018)

Splicing controls the ubiquitin response during DNA double-strand break repair
por: Pederiva, C, et al.
Publicado: (2016)

Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma
por: Farnebo, Lovisa, et al.
Publicado: (2015)

Biomembrane-wrapped gene delivery nanoparticles for cancer therapy
por: Li, Jie, et al.
Publicado: (2023)

Measurements of metastatic renal cell tumours as determined by diffusion weighted imaging or computed tomography are in close agreement, a pilot study
por: Farnebo, J., et al.
Publicado: (2017)

Differentially Expressed Proteins in Intra Synovial Compared to Extra Synovial Flexor Tendon Grafts in a Rabbit Tendon Transplantation Model
por: Farnebo, Simon, et al.
Publicado: (2020)

Sampling insulin in different tissue compartments using microdialysis: methodological aspects
por: Högstedt, Alexandra, et al.
Publicado: (2020)

Investigation of proteins important for microcirculation using in vivo microdialysis after glucose provocation: a proteomic study
por: Högstedt, Alexandra, et al.
Publicado: (2021)

Validation of a smartphone application and wearable sensor for measurements of wrist motions
por: Engstrand, Fredrik, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_u3j92rqgfvkdpjbhhj17b94qhg