si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder

BACKGROUND: In experimental models of fetal alcohol spectrum disorder (FASD), cerebellar hypoplasia and hypofoliation are associated with insulin and insulin-like growth factor (IGF) resistance with impaired signaling through pathways that mediate growth, survival, plasticity, metabolism, and neurot...

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Detalles Bibliográficos
Autores principales: de la Monte, Suzanne M, Tong, Ming, Bowling, Nathaniel, Moskal, Peter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077327/
https://www.ncbi.nlm.nih.gov/pubmed/21443795
http://dx.doi.org/10.1186/1756-6606-4-13

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