Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases

HIV-1 entry requires the cell surface expression of CD4 and either the CCR5 or CXCR4 coreceptors on host cells. Individuals homozygous for the ccr5Δ32 polymorphism do not express CCR5 and are protected from infection by CCR5-tropic (R5) virus strains. As an approach to inactivating CCR5, we introduc...

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Detalles Bibliográficos
Autores principales: Wilen, Craig B., Wang, Jianbin, Tilton, John C., Miller, Jeffrey C., Kim, Kenneth A., Rebar, Edward J., Sherrill-Mix, Scott A., Patro, Sean C., Secreto, Anthony J., Jordan, Andrea P. O., Lee, Gary, Kahn, Joshua, Aye, Pyone P., Bunnell, Bruce A., Lackner, Andrew A., Hoxie, James A., Danet-Desnoyers, Gwenn A., Bushman, Frederic D., Riley, James L., Gregory, Philip D., June, Carl H., Holmes, Michael C., Doms, Robert W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077364/
https://www.ncbi.nlm.nih.gov/pubmed/21533216
http://dx.doi.org/10.1371/journal.ppat.1002020

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