Multifaceted Intervention by the Hsp90 Inhibitor Ganetespib (STA-9090) in Cancer Cells with Activated JAK/STAT Signaling

There is accumulating evidence that dysregulated JAK signaling occurs in a wide variety of cancer types. In particular, mutations in JAK2 can result in the constitutive activation of STAT transcription factors and lead to oncogenic growth. JAK kinases are established Hsp90 client proteins and here w...

Descripción completa

Detalles Bibliográficos
Autores principales: Proia, David A., Foley, Kevin P., Korbut, Tim, Sang, Jim, Smith, Don, Bates, Richard C., Liu, Yuan, Rosenberg, Alex F., Zhou, Dan, Koya, Keizo, Barsoum, James, Blackman, Ronald K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077378/
https://www.ncbi.nlm.nih.gov/pubmed/21533169
http://dx.doi.org/10.1371/journal.pone.0018552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077378/
https://www.ncbi.nlm.nih.gov/pubmed/21533169
http://dx.doi.org/10.1371/journal.pone.0018552

Ejemplares similares