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Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans

A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers of remaining lifespan for Caenorhabditis elegans. In transgenic lines, we expressed fluorescent...

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Detalles Bibliográficos
Autores principales: Sánchez-Blanco, Adolfo, Kim, Stuart K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077391/
https://www.ncbi.nlm.nih.gov/pubmed/21533182
http://dx.doi.org/10.1371/journal.pgen.1002047
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author Sánchez-Blanco, Adolfo
Kim, Stuart K.
author_facet Sánchez-Blanco, Adolfo
Kim, Stuart K.
author_sort Sánchez-Blanco, Adolfo
collection PubMed
description A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers of remaining lifespan for Caenorhabditis elegans. In transgenic lines, we expressed fluorescent reporter constructs from promoters of C. elegans genes whose expression change with age. The expression levels of aging markers in individual worms from a young synchronous population correlated with their remaining lifespan. We identified eight aging markers, with the superoxide dismutase gene sod-3 expression being the best single predictor of remaining lifespan. Correlation with remaining lifespan became stronger if expression from two aging markers was monitored simultaneously, accounting for up to 49% of the variation in individual lifespan. Visualizing the physiological age of chronologically-identical individuals allowed us to show that a major source of lifespan variability is different pathogenicity from individual to individual and that the mechanism involves variable activation of the insulin-signaling pathway.
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spelling pubmed-30773912011-04-29 Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans Sánchez-Blanco, Adolfo Kim, Stuart K. PLoS Genet Research Article A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers of remaining lifespan for Caenorhabditis elegans. In transgenic lines, we expressed fluorescent reporter constructs from promoters of C. elegans genes whose expression change with age. The expression levels of aging markers in individual worms from a young synchronous population correlated with their remaining lifespan. We identified eight aging markers, with the superoxide dismutase gene sod-3 expression being the best single predictor of remaining lifespan. Correlation with remaining lifespan became stronger if expression from two aging markers was monitored simultaneously, accounting for up to 49% of the variation in individual lifespan. Visualizing the physiological age of chronologically-identical individuals allowed us to show that a major source of lifespan variability is different pathogenicity from individual to individual and that the mechanism involves variable activation of the insulin-signaling pathway. Public Library of Science 2011-04-14 /pmc/articles/PMC3077391/ /pubmed/21533182 http://dx.doi.org/10.1371/journal.pgen.1002047 Text en Sánchez-Blanco, Kim. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sánchez-Blanco, Adolfo
Kim, Stuart K.
Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans
title Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans
title_full Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans
title_fullStr Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans
title_full_unstemmed Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans
title_short Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans
title_sort variable pathogenicity determines individual lifespan in caenorhabditis elegans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077391/
https://www.ncbi.nlm.nih.gov/pubmed/21533182
http://dx.doi.org/10.1371/journal.pgen.1002047
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