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Uncoupling protein-2 increases nitric oxide production and TNFAIP3 pathway activation in pancreatic islets
Mutations in the uncoupling protein 2 (Ucp2) gene are linked to type-2 diabetes. Here, a potential mechanism by which lack of UCP2 is cytoprotective in pancreatic β-cells was investigated. Nitric oxide (NO) production was elevated in Ucp2(−/−) islets. Proliferation (cyclin D2, Ccnd2) and anti-apopto...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Society for Endocrinology
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077812/ https://www.ncbi.nlm.nih.gov/pubmed/21321094 http://dx.doi.org/10.1530/JME-10-0117 |