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The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement

In kinetochores, the Ndc80 complex couples the energy in a depolymerizing microtubule to perform the work of moving chromosomes. The complex directly binds microtubules using an unstructured, positively charged N-terminal tail located on Hec1/Ndc80. Hec1/Ndc80 also contains a calponin homology domai...

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Detalles Bibliográficos
Autores principales: Tooley, John G., Miller, Stephanie A., Stukenberg, P. Todd
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078066/
https://www.ncbi.nlm.nih.gov/pubmed/21325630
http://dx.doi.org/10.1091/mbc.E10-07-0626