Cargando…

The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement

In kinetochores, the Ndc80 complex couples the energy in a depolymerizing microtubule to perform the work of moving chromosomes. The complex directly binds microtubules using an unstructured, positively charged N-terminal tail located on Hec1/Ndc80. Hec1/Ndc80 also contains a calponin homology domai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tooley, John G., Miller, Stephanie A., Stukenberg, P. Todd
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078066/ https://www.ncbi.nlm.nih.gov/pubmed/21325630 http://dx.doi.org/10.1091/mbc.E10-07-0626

Ejemplares similares

Multi-modal microtubule binding by the Ndc80 kinetochore complex
por: Alushin, Gregory M., et al.
Publicado: (2012)

Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding
por: Polley, Soumitra, et al.
Publicado: (2023)

Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin
por: Vorozhko, Valeriya V., et al.
Publicado: (2007)

Strain stiffening of Ndc80 complexes attached to microtubule plus ends
por: Schwietert, Felix, et al.
Publicado: (2022)

The Ndc80 Loop Region Facilitates Formation of Kinetochore Attachment to the Dynamic Microtubule Plus End
por: Maure, Jean-François, et al.
Publicado: (2011)

Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments
por: Yoo, Tae Yeon, et al.
Publicado: (2018)

Kinetochore-bound Mps1 regulates kinetochore–microtubule attachments via Ndc80 phosphorylation
por: Sarangapani, Krishna K., et al.
Publicado: (2021)

Orientation and structure of the Ndc80 complex on the microtubule lattice
por: Wilson-Kubalek, Elizabeth M., et al.
Publicado: (2008)

Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling
por: Huis in 't Veld, Pim J, et al.
Publicado: (2019)

Microtubule depolymerization promotes particle and chromosome movement in vitro
Publicado: (1991)

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules
por: Alushin, Gregory M., et al.
Publicado: (2010)

The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore–microtubule attachment in mitosis
por: Sundin, Lynsie J.R., et al.
Publicado: (2011)

Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B
por: Tien, Jerry F., et al.
Publicado: (2010)

Human Ska complex and Ndc80 complex interact to form a load-bearing assembly that strengthens kinetochore–microtubule attachments
por: Helgeson, Luke A., et al.
Publicado: (2018)

Hec1/Ndc80 Tail Domain Function at the Kinetochore-Microtubule Interface
por: Wimbish, Robert T., et al.
Publicado: (2020)

Structure of the Ndc80 complex and its interactions at the yeast kinetochore–microtubule interface
por: Zahm, Jacob A., et al.
Publicado: (2023)

Three interacting regions of the Ndc80 and Dam1 complexes support microtubule tip-coupling under load
por: Flores, Rachel L., et al.
Publicado: (2022)

The Ndc80-Cdt1-Ska1 complex is a central processive kinetochore–microtubule coupling unit
por: Rahi, Amit, et al.
Publicado: (2023)

Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity
por: Zaytsev, Anatoly V., et al.
Publicado: (2015)

Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces
por: Volkov, Vladimir A, et al.
Publicado: (2018)

Tight bending of the Ndc80 complex provides intrinsic regulation of its binding to microtubules
por: Scarborough, Emily Anne, et al.
Publicado: (2019)

The Hec1/Ndc80 tail domain is required for force generation at kinetochores, but is dispensable for kinetochore–microtubule attachment formation and Ska complex recruitment
por: Wimbish, Robert T., et al.
Publicado: (2020)

Molecular requirements for the formation of a kinetochore–microtubule interface by Dam1 and Ndc80 complexes
por: Lampert, Fabienne, et al.
Publicado: (2013)

Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80
por: Kern, David M, et al.
Publicado: (2017)

The internal loop of fission yeast Ndc80 binds Alp7/TACC-Alp14/TOG and ensures proper chromosome attachment
por: Tang, Ngang Heok, et al.
Publicado: (2013)

Effect of NDC80 in human hepatocellular carcinoma
por: Ju, Lin-Ling, et al.
Publicado: (2017)

Temperature dependence of anaphase chromosome velocity and microtubule depolymerization
Publicado: (1975)

MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation
por: Tang, Ngang Heok, et al.
Publicado: (2015)

The Dam1 complex confers microtubule plus end–tracking activity to the Ndc80 kinetochore complex
por: Lampert, Fabienne, et al.
Publicado: (2010)

Alp7/TACC recruits kinesin-8–PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement
por: Tang, Ngang Heok, et al.
Publicado: (2015)

Structural comparison of the Caenorhabditis elegans and human Ndc80 complexes bound to microtubules reveals distinct binding behavior
por: Wilson-Kubalek, Elizabeth M., et al.
Publicado: (2016)

Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80
por: Pesenti, Marion E., et al.
Publicado: (2018)

Purification and characterisation of the fission yeast Ndc80 complex
por: Matsuo, Yuzy, et al.
Publicado: (2017)

Meiotic regulation of the Ndc80 complex composition and function
por: Chen, Jingxun, et al.
Publicado: (2021)

Coordination between the Ndc80 complex and dynein is essential for microtubule plus-end capture by kinetochores during early mitosis
por: Amin, Mohammed Abdullahel, et al.
Publicado: (2023)

Ndc80 Internal Loop Interacts with Dis1/TOG to Ensure Proper Kinetochore-Spindle Attachment in Fission Yeast
por: Hsu, Kuo-Shun, et al.
Publicado: (2011)

Ndc80 Loop as a protein-protein interaction motif
por: Tang, Ngang Heok, et al.
Publicado: (2013)

Dynamics of microtubule depolymerization in monocytes
Publicado: (1986)

Multisite phosphorylation determines the formation of Ska–Ndc80 macro-complexes that are essential for chromosome segregation during mitosis
por: Zhang, Qian, et al.
Publicado: (2020)

Real-time dynamics of Plasmodium NDC80 reveals unusual modes of chromosome segregation during parasite proliferation
por: Zeeshan, Mohammad, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bn27t6pdci7g7tpc8tlgtfarlk