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Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling

Desmocollin-2 (Dsc2) and desmoglein-2 (Dsg2) are transmembrane cell adhesion proteins of desmosomes. Reduced expression of Dsc2 has been reported in colorectal carcinomas, suggesting that Dsc2 may play a role in the development and/or progression of colorectal cancer. However, no studies have examin...

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Detalles Bibliográficos
Autores principales:	Kolegraff, Keli, Nava, Porfirio, Helms, My N., Parkos, Charles A., Nusrat, Asma
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078068/ https://www.ncbi.nlm.nih.gov/pubmed/21325624 http://dx.doi.org/10.1091/mbc.E10-10-0845

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