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Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited

Mitosis requires precise coordination of multiple global reorganizations of the nucleus and cytoplasm. Cyclin-dependent kinase 1 (Cdk1) is the primary upstream kinase that directs mitotic progression by phosphorylation of a large number of substrate proteins. Cdk1 activation reaches the peak level d...

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Detalles Bibliográficos
Autores principales:	Potapova, Tamara A., Sivakumar, Sushama, Flynn, Jennifer N., Li, Rong, Gorbsky, Gary J.
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078080/ https://www.ncbi.nlm.nih.gov/pubmed/21325631 http://dx.doi.org/10.1091/mbc.E10-07-0599

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