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Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus

Increasing attention is now being given to the epigenetic regulation of animal and human behaviors including the stress response and drug addiction. Epigenetic factors also influence feeding behavior and metabolic phenotypes, such as obesity and insulin sensitivity. In response to fasting and high-f...

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Autores principales: Funato, Hiromasa, Oda, Satoko, Yokofujita, Junko, Igarashi, Hiroaki, Kuroda, Masaru
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078138/
https://www.ncbi.nlm.nih.gov/pubmed/21526203
http://dx.doi.org/10.1371/journal.pone.0018950
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author Funato, Hiromasa
Oda, Satoko
Yokofujita, Junko
Igarashi, Hiroaki
Kuroda, Masaru
author_facet Funato, Hiromasa
Oda, Satoko
Yokofujita, Junko
Igarashi, Hiroaki
Kuroda, Masaru
author_sort Funato, Hiromasa
collection PubMed
description Increasing attention is now being given to the epigenetic regulation of animal and human behaviors including the stress response and drug addiction. Epigenetic factors also influence feeding behavior and metabolic phenotypes, such as obesity and insulin sensitivity. In response to fasting and high-fat diets, the medial hypothalamus changes the expression of neuropeptides regulating feeding, metabolism, and reproductive behaviors. Histone deacetylases (HDACs) are involved in the epigenetic control of gene expression and alter behavior in response to a variety of environmental factors. Here, we examined the expression of HDAC family members in the medial hypothalamus of mice in response to either fasting or a high-fat diet. In response to fasting, HDAC3 and −4 expression levels increased while HDAC10 and −11 levels decreased. Four weeks on a high-fat diet resulted in the increased expression of HDAC5 and −8. Moreover, fasting decreased the number of acetylated histone H3- and acetylated histone H4-positive cells in the ventrolateral subdivision of the ventromedial hypothalamus. Therefore, HDACs may be implicated in altered gene expression profiles in the medial hypothalamus under different metabolic states.
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spelling pubmed-30781382011-04-27 Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus Funato, Hiromasa Oda, Satoko Yokofujita, Junko Igarashi, Hiroaki Kuroda, Masaru PLoS One Research Article Increasing attention is now being given to the epigenetic regulation of animal and human behaviors including the stress response and drug addiction. Epigenetic factors also influence feeding behavior and metabolic phenotypes, such as obesity and insulin sensitivity. In response to fasting and high-fat diets, the medial hypothalamus changes the expression of neuropeptides regulating feeding, metabolism, and reproductive behaviors. Histone deacetylases (HDACs) are involved in the epigenetic control of gene expression and alter behavior in response to a variety of environmental factors. Here, we examined the expression of HDAC family members in the medial hypothalamus of mice in response to either fasting or a high-fat diet. In response to fasting, HDAC3 and −4 expression levels increased while HDAC10 and −11 levels decreased. Four weeks on a high-fat diet resulted in the increased expression of HDAC5 and −8. Moreover, fasting decreased the number of acetylated histone H3- and acetylated histone H4-positive cells in the ventrolateral subdivision of the ventromedial hypothalamus. Therefore, HDACs may be implicated in altered gene expression profiles in the medial hypothalamus under different metabolic states. Public Library of Science 2011-04-15 /pmc/articles/PMC3078138/ /pubmed/21526203 http://dx.doi.org/10.1371/journal.pone.0018950 Text en Funato et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Funato, Hiromasa
Oda, Satoko
Yokofujita, Junko
Igarashi, Hiroaki
Kuroda, Masaru
Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus
title Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus
title_full Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus
title_fullStr Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus
title_full_unstemmed Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus
title_short Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus
title_sort fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078138/
https://www.ncbi.nlm.nih.gov/pubmed/21526203
http://dx.doi.org/10.1371/journal.pone.0018950
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