Cargando…
Primary Tumor Volume Is an Independent Predictor of Outcome Within pT4a-Staged Tongue Carcinoma
BACKGROUND: We evaluated the heterogeneity of primary tumor volume (PTV) within tumors of the same pT4a-staged tongue carcinoma and to elucidate the effects of PTV on treatment outcomes in patients with pT4a-staged tongue carcinoma. METHODS: Fifty-eight patients with newly diagnosed pT4a-staged tong...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078304/ https://www.ncbi.nlm.nih.gov/pubmed/21174152 http://dx.doi.org/10.1245/s10434-010-1489-y |
_version_ | 1782201941835644928 |
---|---|
author | Chen, Mu-Kuan Chen, Chih-Ming Lee, Ming-Che Chen, Li-Sheng Chen, Hui-Chuan |
author_facet | Chen, Mu-Kuan Chen, Chih-Ming Lee, Ming-Che Chen, Li-Sheng Chen, Hui-Chuan |
author_sort | Chen, Mu-Kuan |
collection | PubMed |
description | BACKGROUND: We evaluated the heterogeneity of primary tumor volume (PTV) within tumors of the same pT4a-staged tongue carcinoma and to elucidate the effects of PTV on treatment outcomes in patients with pT4a-staged tongue carcinoma. METHODS: Fifty-eight patients with newly diagnosed pT4a-staged tongue carcinoma who received surgery were enrolled onto this study. Magnetic resonance imaging–derived PTV was measured by the summation-of-area technique. RESULTS: The mean PTV was 24.55 ml, with a range of 5.32 to 119.64 ml. The receiver operating characteristic curve was applied, and the optimal cutoff volume was 23 ml. Large PTV was associated with a significantly poor disease-specific survival (P = 0.010) by the log rank test. The Cox regression model also revealed that large PTV (P = 0.026) and positive lymphatic node metastasis (P = 0.004) were statistically significant in the prognosis of T4a-staged tongue carcinoma. CONCLUSIONS: A substantial variation of PTV was present within the same pT4a-staged tongue carcinoma, and PTV represented an important prognostic factor. In the light of these findings, we suggest that taking the PTV into account in pT4a-staged tongue carcinoma would better refine the newest revised T classification, and the treatment strategies may be different. |
format | Text |
id | pubmed-3078304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-30783042011-05-26 Primary Tumor Volume Is an Independent Predictor of Outcome Within pT4a-Staged Tongue Carcinoma Chen, Mu-Kuan Chen, Chih-Ming Lee, Ming-Che Chen, Li-Sheng Chen, Hui-Chuan Ann Surg Oncol Head and Neck Oncology BACKGROUND: We evaluated the heterogeneity of primary tumor volume (PTV) within tumors of the same pT4a-staged tongue carcinoma and to elucidate the effects of PTV on treatment outcomes in patients with pT4a-staged tongue carcinoma. METHODS: Fifty-eight patients with newly diagnosed pT4a-staged tongue carcinoma who received surgery were enrolled onto this study. Magnetic resonance imaging–derived PTV was measured by the summation-of-area technique. RESULTS: The mean PTV was 24.55 ml, with a range of 5.32 to 119.64 ml. The receiver operating characteristic curve was applied, and the optimal cutoff volume was 23 ml. Large PTV was associated with a significantly poor disease-specific survival (P = 0.010) by the log rank test. The Cox regression model also revealed that large PTV (P = 0.026) and positive lymphatic node metastasis (P = 0.004) were statistically significant in the prognosis of T4a-staged tongue carcinoma. CONCLUSIONS: A substantial variation of PTV was present within the same pT4a-staged tongue carcinoma, and PTV represented an important prognostic factor. In the light of these findings, we suggest that taking the PTV into account in pT4a-staged tongue carcinoma would better refine the newest revised T classification, and the treatment strategies may be different. Springer-Verlag 2010-12-21 2011 /pmc/articles/PMC3078304/ /pubmed/21174152 http://dx.doi.org/10.1245/s10434-010-1489-y Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Head and Neck Oncology Chen, Mu-Kuan Chen, Chih-Ming Lee, Ming-Che Chen, Li-Sheng Chen, Hui-Chuan Primary Tumor Volume Is an Independent Predictor of Outcome Within pT4a-Staged Tongue Carcinoma |
title | Primary Tumor Volume Is an Independent Predictor of Outcome Within pT4a-Staged Tongue Carcinoma |
title_full | Primary Tumor Volume Is an Independent Predictor of Outcome Within pT4a-Staged Tongue Carcinoma |
title_fullStr | Primary Tumor Volume Is an Independent Predictor of Outcome Within pT4a-Staged Tongue Carcinoma |
title_full_unstemmed | Primary Tumor Volume Is an Independent Predictor of Outcome Within pT4a-Staged Tongue Carcinoma |
title_short | Primary Tumor Volume Is an Independent Predictor of Outcome Within pT4a-Staged Tongue Carcinoma |
title_sort | primary tumor volume is an independent predictor of outcome within pt4a-staged tongue carcinoma |
topic | Head and Neck Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078304/ https://www.ncbi.nlm.nih.gov/pubmed/21174152 http://dx.doi.org/10.1245/s10434-010-1489-y |
work_keys_str_mv | AT chenmukuan primarytumorvolumeisanindependentpredictorofoutcomewithinpt4astagedtonguecarcinoma AT chenchihming primarytumorvolumeisanindependentpredictorofoutcomewithinpt4astagedtonguecarcinoma AT leemingche primarytumorvolumeisanindependentpredictorofoutcomewithinpt4astagedtonguecarcinoma AT chenlisheng primarytumorvolumeisanindependentpredictorofoutcomewithinpt4astagedtonguecarcinoma AT chenhuichuan primarytumorvolumeisanindependentpredictorofoutcomewithinpt4astagedtonguecarcinoma |