PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1

LIMD1 is a tumour suppressor gene (TSG) down regulated in ∼80% of lung cancers with loss also demonstrated in breast and head and neck squamous cell carcinomas. LIMD1 is also a candidate TSG in childhood acute lymphoblastic leukaemia. Mechanistically, LIMD1 interacts with pRB, repressing E2F-driven...

Descripción completa

Detalles Bibliográficos
Autores principales: Foxler, Daniel E., James, Victoria, Shelton, Samuel J., Vallim, Thomas Q. de A., Shaw, Peter E., Sharp, Tyson V.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078326/
https://www.ncbi.nlm.nih.gov/pubmed/21402070
http://dx.doi.org/10.1016/j.febslet.2011.03.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078326/
https://www.ncbi.nlm.nih.gov/pubmed/21402070
http://dx.doi.org/10.1016/j.febslet.2011.03.013

Ejemplares similares