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PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1
LIMD1 is a tumour suppressor gene (TSG) down regulated in ∼80% of lung cancers with loss also demonstrated in breast and head and neck squamous cell carcinomas. LIMD1 is also a candidate TSG in childhood acute lymphoblastic leukaemia. Mechanistically, LIMD1 interacts with pRB, repressing E2F-driven...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science B.V
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078326/ https://www.ncbi.nlm.nih.gov/pubmed/21402070 http://dx.doi.org/10.1016/j.febslet.2011.03.013 |