Cargando…
Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility. Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell-dependent colitis; however, the cell populations it acts on to induce intestinal immune pathology are unknown. Here, using Il...
Autores principales: | Ahern, Philip P., Schiering, Chris, Buonocore, Sofia, McGeachy, Mandy J., Cua, Dan J., Maloy, Kevin J., Powrie, Fiona |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078329/ https://www.ncbi.nlm.nih.gov/pubmed/20732640 http://dx.doi.org/10.1016/j.immuni.2010.08.010 |
Ejemplares similares
-
Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
por: Ahern, Philip P., et al.
Publicado: (2011) -
Interleukin-23 drives innate and T cell–mediated intestinal inflammation
por: Hue, Sophie, et al.
Publicado: (2006) -
Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis
por: Izcue, Ana, et al.
Publicado: (2008) -
Innate lymphoid cells drive IL-23 dependent innate intestinal pathology
por: Buonocore, Sofia, et al.
Publicado: (2010) -
Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation
por: Griseri, Thibault, et al.
Publicado: (2012)