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Critical diaphragm failure in sudden infant death syndrome

Sudden infant death syndrome (SIDS) is the leading cause of death in infants between the ages of 1 and 12 months in developed countries. SIDS is by definition a diagnosis of exclusion, and its mechanism of action is unknown. The SIDS–Critical Diaphragm Failure (CDF) hypothesis postulates that the ca...

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Autores principales: Siren, Pontus Max Axel, Siren, Matti Juhani
Formato: Texto
Lenguaje:English
Publicado: Informa Healthcare 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078540/
https://www.ncbi.nlm.nih.gov/pubmed/21222555
http://dx.doi.org/10.3109/03009734.2010.548011
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author Siren, Pontus Max Axel
Siren, Matti Juhani
author_facet Siren, Pontus Max Axel
Siren, Matti Juhani
author_sort Siren, Pontus Max Axel
collection PubMed
description Sudden infant death syndrome (SIDS) is the leading cause of death in infants between the ages of 1 and 12 months in developed countries. SIDS is by definition a diagnosis of exclusion, and its mechanism of action is unknown. The SIDS–Critical Diaphragm Failure (CDF) hypothesis postulates that the cause of death in SIDS is respiratory failure caused by CDF. Four principal risk factors contribute to CDF in young infants: undeveloped respiratory muscles, non-lethal infections, prone resting position, and REM sleep. Even relatively minor infections can cause an acute and significant reduction in diaphragm force generation capacity that in conjunction with other risk factors can precipitate CDF. CDF-induced acute muscle weakness leaves few, if any pathological marks on the affected tissue.Understanding the underlying mechanism of SIDS may help in formulating new approaches to child care that can help to further reduce the incidence of SIDS.
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spelling pubmed-30785402011-05-01 Critical diaphragm failure in sudden infant death syndrome Siren, Pontus Max Axel Siren, Matti Juhani Ups J Med Sci Original Article Sudden infant death syndrome (SIDS) is the leading cause of death in infants between the ages of 1 and 12 months in developed countries. SIDS is by definition a diagnosis of exclusion, and its mechanism of action is unknown. The SIDS–Critical Diaphragm Failure (CDF) hypothesis postulates that the cause of death in SIDS is respiratory failure caused by CDF. Four principal risk factors contribute to CDF in young infants: undeveloped respiratory muscles, non-lethal infections, prone resting position, and REM sleep. Even relatively minor infections can cause an acute and significant reduction in diaphragm force generation capacity that in conjunction with other risk factors can precipitate CDF. CDF-induced acute muscle weakness leaves few, if any pathological marks on the affected tissue.Understanding the underlying mechanism of SIDS may help in formulating new approaches to child care that can help to further reduce the incidence of SIDS. Informa Healthcare 2011-05 2011-04-12 /pmc/articles/PMC3078540/ /pubmed/21222555 http://dx.doi.org/10.3109/03009734.2010.548011 Text en © Upsala Medical Society http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Original Article
Siren, Pontus Max Axel
Siren, Matti Juhani
Critical diaphragm failure in sudden infant death syndrome
title Critical diaphragm failure in sudden infant death syndrome
title_full Critical diaphragm failure in sudden infant death syndrome
title_fullStr Critical diaphragm failure in sudden infant death syndrome
title_full_unstemmed Critical diaphragm failure in sudden infant death syndrome
title_short Critical diaphragm failure in sudden infant death syndrome
title_sort critical diaphragm failure in sudden infant death syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078540/
https://www.ncbi.nlm.nih.gov/pubmed/21222555
http://dx.doi.org/10.3109/03009734.2010.548011
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