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Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis

BACKGROUND: Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance. METHODS: We investigated whether acquired cisplatin resistance affects sensitivity to re...

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Detalles Bibliográficos
Autores principales:	Duiker, E W, Meijer, A, van der Bilt, A R M, Meersma, G J, Kooi, N, van der Zee, A G J, de Vries, E G, de Jong, S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078595/ https://www.ncbi.nlm.nih.gov/pubmed/21487429 http://dx.doi.org/10.1038/bjc.2011.84

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