Cargando…

Structure of Mammalian AMPK and its regulation by ADP

The heterotrimeric AMP-activated protein kinase (AMPK) plays a key role in regulating cellular energy metabolism; in response to a fall in intracellular ATP levels it activates energy producing pathways and inhibits energy consuming processes1. AMPK has been implicated in a number of diseases relate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Bing, Sanders, Matthew J., Underwood, Elizabeth, Heath, Richard, Mayer, Faith, Carmena, David, Jing, Chun, Walker, Philip A., Eccleston, John F., Haire, Lesley F., Saiu, Peter, Howell, Steven A., Aasland, Rein, Martin, Stephen R., Carling, David, Gamblin, Steven J.
Formato:	Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078618/ https://www.ncbi.nlm.nih.gov/pubmed/21399626 http://dx.doi.org/10.1038/nature09932

Ejemplares similares

ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase
por: Mayer, Faith V., et al.
Publicado: (2011)

Structural basis of AMPK regulation by small molecule activators
por: Xiao, Bing, et al.
Publicado: (2013)

Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells
por: Willows, Robin, et al.
Publicado: (2017)

Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet
por: Woods, Angela, et al.
Publicado: (2017)

AMPK Function in Mammalian Spermatozoa
por: Martin-Hidalgo, David, et al.
Publicado: (2018)

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
por: Justin, Neil, et al.
Publicado: (2016)

Poly(ADP-ribosyl)ation in mammalian ageing
por: Beneke, Sascha, et al.
Publicado: (2007)

Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export
por: Rodríguez-Vargas, José M, et al.
Publicado: (2016)

Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP
por: Auciello, F. Romana, et al.
Publicado: (2014)

Mammalian γ2 AMPK regulates intrinsic heart rate
por: Yavari, Arash, et al.
Publicado: (2017)

Effect of different γ-subunit isoforms on the regulation of AMPK
por: Willows, Robin, et al.
Publicado: (2017)

Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms
por: Ross, Fiona A., et al.
Publicado: (2016)

Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue
por: Martello, Rita, et al.
Publicado: (2016)

The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin
por: Withers-Martinez, Chrislaine, et al.
Publicado: (2014)

Corrigendum: The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin
por: Withers-Martinez, Chrislaine, et al.
Publicado: (2014)

Cryo-electron microscopy structures of pyrene-labeled ADP-P(i)- and ADP-actin filaments
por: Chou, Steven Z., et al.
Publicado: (2020)

ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and multiple PARPs
por: Weixler, Lisa, et al.
Publicado: (2022)

Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase
por: Aleshin, Vasily A., et al.
Publicado: (2022)

Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering
por: Jørgensen, Nicolas O., et al.
Publicado: (2021)

Roles of AMP-Activated Protein Kinase (AMPK) in Mammalian Reproduction
por: Yang, Weina, et al.
Publicado: (2020)

The orthologue of the "acatalytic" mammalian ART4 in chicken is an arginine-specific mono-ADP-ribosyltransferase
por: Grahnert, Andreas, et al.
Publicado: (2008)

Imaging of Metabolic Status in 3D Cultures with an Improved AMPK FRET Biosensor for FLIM
por: Chennell, George, et al.
Publicado: (2016)

Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells
por: Ernst, Katharina, et al.
Publicado: (2017)

Impact of Dabigatran versus Phenprocoumon on ADP Induced Platelet Aggregation in Patients with Atrial Fibrillation with or without Concomitant Clopidogrel Therapy (the Dabi-ADP-1 and Dabi-ADP-2 Trials)
por: Martischnig, Amadea M., et al.
Publicado: (2015)

Proteolytic activity assayed by subcellular localization switching of a substrate
por: Szilvay, Anne-Marie, et al.
Publicado: (2016)

A dual role for AMP‐activated protein kinase (AMPK) during neonatal hypoxic–ischaemic brain injury in mice
por: Rousset, Catherine I., et al.
Publicado: (2015)

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly
por: Hinchy, Elizabeth C., et al.
Publicado: (2018)

Crystallization of SHARPIN using an automated two-dimensional grid screen for optimization
por: Stieglitz, Benjamin, et al.
Publicado: (2012)

Bimodal and Hysteretic Expression in Mammalian Cells from a Synthetic Gene Circuit
por: May, Tobias, et al.
Publicado: (2008)

LKB1 Is an Essential Regulator of Spermatozoa Release during Spermiation in the Mammalian Testis
por: Denison, Fiona C., et al.
Publicado: (2011)

Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome
por: Estève, Pierre-Olivier, et al.
Publicado: (2022)

Structure-based Mechanism of ADP-ribosylation by Sirtuins
por: Hawse, William F., et al.
Publicado: (2009)

ADP: the missing link between thrombosis and hemolysis
por: Gerber, Gloria F., et al.
Publicado: (2023)

Poly (ADP-ribose) polymerase inhibitor, an effective radiosensitizer in lung and pancreatic cancers
por: Hastak, Kedar, et al.
Publicado: (2017)

e. ADP Project
Publicado: (1967)

Polymerization of ADP-actin
Publicado: (1984)

ADP-ribosylation of arginine
por: Laing, Sabrina, et al.
Publicado: (2010)

ADP Progress Report
Publicado: (1970)

ADP Services Review
por: Ferguson, J
Publicado: (1986)

Reversing ADP-ribosylation
por: Moeller, Giuliana Katharina, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_28lb68flj1bvp08qevoaajp91m