Cytosine Methyltransferases as Tumor Markers

Changes in DNA methylation patterns is a prominent characteristic of human tumors. Tumor cells display reduced levels of genomic DNA methylation and site-specific CpG island hypermethylation. Methylation of CpG dinucleotides is catalyzed by the enzyme family of DNA methyltransferases (DNMTs). In thi...

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Detalles Bibliográficos
Autores principales: Pavlopoulou, Athanasia, Kossida, Sophia
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078681/
https://www.ncbi.nlm.nih.gov/pubmed/21629434
http://dx.doi.org/10.2174/138920210793360916
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author Pavlopoulou, Athanasia
Kossida, Sophia
author_facet Pavlopoulou, Athanasia
Kossida, Sophia
author_sort Pavlopoulou, Athanasia
collection PubMed
description Changes in DNA methylation patterns is a prominent characteristic of human tumors. Tumor cells display reduced levels of genomic DNA methylation and site-specific CpG island hypermethylation. Methylation of CpG dinucleotides is catalyzed by the enzyme family of DNA methyltransferases (DNMTs). In this review, the role of DNA methylation and DNMTs as key determinants of carcinogenesis is further elucidated. The chromatin modifying proteins that are known to interact with DNMTs are also described. Finally, the role of DNMTs as potential therapeutic targets is addressed.
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spelling pubmed-30786812011-06-01 Cytosine Methyltransferases as Tumor Markers Pavlopoulou, Athanasia Kossida, Sophia Curr Genomics Article Changes in DNA methylation patterns is a prominent characteristic of human tumors. Tumor cells display reduced levels of genomic DNA methylation and site-specific CpG island hypermethylation. Methylation of CpG dinucleotides is catalyzed by the enzyme family of DNA methyltransferases (DNMTs). In this review, the role of DNA methylation and DNMTs as key determinants of carcinogenesis is further elucidated. The chromatin modifying proteins that are known to interact with DNMTs are also described. Finally, the role of DNMTs as potential therapeutic targets is addressed. Bentham Science Publishers Ltd 2010-12 /pmc/articles/PMC3078681/ /pubmed/21629434 http://dx.doi.org/10.2174/138920210793360916 Text en ©2010 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Pavlopoulou, Athanasia
Kossida, Sophia
Cytosine Methyltransferases as Tumor Markers
title Cytosine Methyltransferases as Tumor Markers
title_full Cytosine Methyltransferases as Tumor Markers
title_fullStr Cytosine Methyltransferases as Tumor Markers
title_full_unstemmed Cytosine Methyltransferases as Tumor Markers
title_short Cytosine Methyltransferases as Tumor Markers
title_sort cytosine methyltransferases as tumor markers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078681/
https://www.ncbi.nlm.nih.gov/pubmed/21629434
http://dx.doi.org/10.2174/138920210793360916
work_keys_str_mv AT pavlopoulouathanasia cytosinemethyltransferasesastumormarkers
AT kossidasophia cytosinemethyltransferasesastumormarkers

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